Inflammation gene variants and susceptibility to albuminuria in the U.S. population: analysis in the Third National Health and Nutrition Examination Survey (NHANES III), 1991-1994

Ned, Renée M; Yesupriya, Ajay; Imperatore, Giuseppina; Smelser, Diane T; Moonesinghe, Ramal; Chang, Man-huei; Dowling, Nicole F

doi:10.1186/1471-2350-11-155

Table 4 Significant associations of candidate gene polymorphisms and sex-specific albuminuria^a, additive genetic model

From: Inflammation gene variants and susceptibility to albuminuria in the U.S. population: analysis in the Third National Health and Nutrition Examination Survey (NHANES III), 1991-1994

	Crude Model			Fully Adjusted^bModel
Variant	OR (95% CI)	P-value	FDR-adjusted P-value	OR (95% CI)	P-value	FDR-adjusted P-value
*Non-Hispanic whites*
rs1800750 (TNF)	2.38 (1.56-3.63)	0.0003	0.0180	2.74 (1.34-5.61)	0.0079	0.2370
rs361525 (TNF)	1.59 (1.07-2.36)	0.0235	0.7050	1.99 (1.23-3.25)	0.0075	0.2370
rs731236 (VDR)	1.27 (1.01-1.58)	0.0404	0.7904	1.16 (0.95-1.42)	0.1278	0.9818
*Non-Hispanic blacks*
rs2808630 (CRP)	1.39 (1.12-1.72)	0.0041	0.2460	1.30 (1.04-1.64)	0.0232	0.4515
rs3093058 (CRP)	0.67 (0.49-0.91)	0.0134	0.4020	0.66 (0.48-0.89)	0.0091	0.4515
rs7096206 (MBL2)	0.70 (0.50-0.99)	0.0423	0.5340	0.66 (0.44-1.01)	0.0530	0.5280
rs1800468 (TGFB1/B9D2)	0.48 (0.24-0.96)	0.0384	0.5340	0.44 (0.18-1.05)	0.0622	0.5280
rs1800629 (TNF)	0.69 (0.47-0.99)	0.0468	0.5340	0.79 (0.54-1.16)	0.2172	0.8145
rs731236 (VDR)	1.25 (0.98-1.59)	0.0736	0.6309	1.33 (1.03-1.72)	0.0301	0.4515
rs890945 (Chr 5q33.3)	0.78 (0.61-1.00)	0.0534	0.5340	0.71 (0.53-0.95)	0.0236	0.4515
*Mexican Americans*
rs11265260 (CRP)	0.39 (0.21-0.72)	0.0041	0.1121	0.51 (0.29-0.92)	0.0274	0.3202
rs3093075 (CRP)	0.40 (0.22-0.75)	0.0057	0.1121	0.45 (0.26-0.80)	0.0088	0.2069
rs1143623 (IL1B)	1.24 (1.09-1.40)	0.0022	0.1121	1.46 (1.28-1.67)	< 0.0001	< 0.0001
rs1800871 (IL10)	1.29 (1.03-1.62)	0.0267	0.3151	1.22 (0.91-1.62)	0.1753	0.5084
rs1800872 (IL10)	1.30 (1.04-1.64)	0.0242	0.3151	1.22 (0.91-1.63)	0.1673	0.5084
rs2070744 (NOS3)	0.76 (0.54-1.08)	0.1157	0.5012	0.67 (0.47-0.95)	0.0276	0.3202
rs1800629 (TNF)	0.63 (0.38-1.04)	0.0697	0.4745	0.56 (0.36-0.86)	0.0107	0.2069

CI, confidence interval; FDR, false-discovery rate; OR, odds ratio.
a) Defined as urinary albumin-to-creatinine ratio (ACR) above sex-specific thresholds (≥ 17 mg/g in men and ≥ 25 mg/g in women). b) Analyses adjusted for age, alcohol consumption, educational attainment, and waist:hip ratio.

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