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Table 1 Characteristics of included study participants (≥ 20 years old), NHANES III DNA bank, 1991-1994

From: Inflammation gene variants and susceptibility to albuminuria in the U.S. population: analysis in the Third National Health and Nutrition Examination Survey (NHANES III), 1991-1994

   

ACR

Albuminuriab

Characteristic

Unweighted sample size

(N)

Weighted frequency

(%a)

Geometric mean (mg/g) ± SE

P-value

Prevalence (%a) ± SD

P-value

Gender

      

   Female

2884

49.38

6.40 ± 0.33

< 0.0001

12.15 ± 1.12

0.1548

   Male

2437

50.62

4.28 ± 0.28

 

9.84 ± 1.10

 

Age (years)

      

   20-50

3018

62.75

3.93 ± 0.20

< 0.0001

5.04 ± 0.62

< 0.0001

   ≥ 50

2303

37.25

8.48 ± 0.45

 

21.10 ± 1.41

 

Race/ethnicity

      

   Non-Hispanic white

2249

82.35

5.32 ± 0.30

0.1486

10.44 ± 0.89

0.0021

   Non-Hispanic black

1502

11.96

4.95 ± 0.28

 

14.99 ± 1.11

 

   Mexican-American

1570

5.69

4.50 ± 0.34

 

10.40 ± 0.99

 

Education

      

   < high school

2016

21.57

6.73 ± 0.42

0.0001

16.55 ± 1.36

< 0.0001

   Completed high school

1706

34.54

5.58 ± 0.32

 

12.67 ± 1.00

 

   > high school

1570

43.89

4.40 ± 0.30

 

7.02 ± 0.73

 

Smoking status

      

   Non-smoker

2748

47.10

4.88 ± 0.36

0.0595

10.28 ± 0.99

0.1464

   Former smoker

1294

26.54

5.86 ± 0.31

 

12.73 ± 1.09

 

   Current smoker

1279

26.36

5.26 ± 0.30

 

10.47 ± 1.20

 

Alcohol use

      

   None

2838

46.09

6.45 ± 0.29

< 0.0001

14.42 ± 1.20

0.0001

   1-3 drinks/week

1156

27.63

4.62 ± 0.38

 

7.76 ± 0.97

 

   ≥ 4 drinks/week

1145

26.28

4.07 ± 0.29

 

7.88 ± 1.15

 

Waist:hip ratio c

      

   Low

1565

35.89

4.57 ± 0.25

0.0007

6.29 ± 0.82

0.0001

   High

3539

64.11

5.56 ± 0.28

 

12.94 ± 1.11

 

Diabetes d

      

   No

4921

94.85

4.88 ± 0.23

< 0.0001

9.21 ± 0.64

< 0.0001

   Yes

399

5.15

18.96 ± 3.16

 

44.03 ± 4.98

 

Serum CRP level (mg/dL)

      

   < 1

4747

92.35

4.98 ± 0.25

< 0.0001

9.96 ± 0.63

< 0.0001

   ≥ 1

549

7.65

9.47 ± 0.99

 

23.68 ± 3.89

 

Hypertension e

      

   No

3653

75.32

4.21 ± 0.21

< 0.0001

6.09 ± 0.59

< 0.0001

   Yes

1659

24.68

10.26 ± 0.57

 

26.17 ± 1.95

 

eGFR (ml/min/1.73 m 2 )

      

   ≥ 60

4882

93.84

4.85 ± 0.24

< 0.0001

9.24 ± 0.74

< 0.0001

   < 60

406

6.16

16.16 ± 1.74

 

37.81 ± 2.85

 
  1. ACR, albumin-to-creatinine ratio; CRP, C-reactive protein; eGFR, estimated glomerular filtration rate; NHANES III, Third National Health and Nutrition Examination Survey; SD, standard deviation; SE, standard error.
  2. a) Weighted percentage based on NHANES survey weights. b) Defined as ACR ≥ 17 mg/g in men and ≥ 25 mg/g in women. c) Defined by sex-specific cut-offs: males = 0.90; females = 0.85. d) Defined as self-reported diabetes (answering "yes" to "ever been told you have sugar/diabetes"), but excluding women with a history of only gestational diabetes. e) Defined as systolic blood pressure (bp) ≥ 140 mmHg, diastolic bp ≥ 90 mmHg, or currently taking prescribed medicine for hypertension.
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BMC Medical Genetics

ISSN: 1471-2350

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