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Table 1 Clinical and biological characteristics of subjects according to SNP of the Clock gene

From: The association of the Clock 3111 T/C SNP with lipids and lipoproteins including small dense low-density lipoprotein: results from the Mima study

Parameters

T/T

T/C

C/C

T/T + T/C

T/C + C/C

P value

Number

277

77

11

354

88

 

Age (years)

64 ± 14

65 ± 13

61 ± 17

64 ± 14

65 ± 14

0.559

Sex (men/women)

132/145

31/46

7/4

163/191

38/50

0.464

Skipping breakfast (%)

5

9

0

6

8

0.390

Smoking (current, %)

14

25

27

26

16

0.249

Exercise habit (none/done, %)

72/18

70/30

54/46

71/29

68/32

0.061

Sleeping time (%)a

      

   < 6 hours

21.2

19.5

27.3

20.9

20.4

 

   6 hours

20.9

10.4

0

18.6

9.1

 

   7 hours

25.3

31.1

27.3

26.6

30.7

0.090

   8 hours

24.2

33.8

27.3

26.3

33.0

 

   ≥ 9 hours

8.4

5.2

18.1

7.7

6.8

 

Body mass index (kg/m2)

24.0 ± 3.0

23.6 ± 3.3

25.8 ± 4.4

23.9 ± 3.1

23.9 ± 3.5

0.061

Systolic blood pressure (mmHg)

137 ± 19

134 ± 20

134 ± 21

136 ± 19

134 ± 20

0.228

Diastolic blood pressure (mmHg)

76 ± 12

76 ± 11

73 ± 15

76 ± 12

76 ± 11

0.735

Fasting plasma glucose (mmol/L)

5.7 ± 1.7

5.5 ± 1.9

5.9 ± 1.7

5.7 ± 1.7

5.6 ± 1.9

0.578

Fasting serum insulin (pmol/L)

47 ± 51

40 ± 29

35 ± 16

46 ± 47

40 ± 27

0.193

HOMA-IR

2.1 ± 2.9

1.8 ± 2.6

1.5 ± 0.7

2.1 ± 2.9

1.8 ± 2.5

0.331

Triglycerides (mmol/L)

1.13 ± 0.58

1.10 ± 0.51

1.00 ± 0.25

1.12 ± 0.57

1.09 ± 0.49

0.580

Total cholesterol (mmol/L)

4.84 ± 0.93

4.78 ± 0.88

4.29 ± 0.83

4.84 ± 0.91

4.73 ± 0.88

0.335

HDL-cholesterol (mmol/L)

1.42 ± 0.41

1.40 ± 0.36

1.40 ± 0.39

1.42 ± 0.39

1.42 ± 0.36

0.875

Small dense LDL (%)

1.7 ± 3.4

0.9 ± 2.0

0.3 ± 0.7

1.6 ± 3.2

0.8 ± 1.9

0.020

  1. Data are means ± SD.
  2. HOMA-IR, homeostasis model assessment of insulin resistance; HDL, high-density lipoprotein; LDL,
  3. low-density lipoprotein
  4. P values in a comparison between subjects with T/T genotype and those with T/C or C/C (by using Student's unpaired t-test and χ2-test).
  5. In another model (T/T + T/C vs. C/C), there were no significant differences in various traits (by using Student's unpaired t-test and χ2-test).
  6. a Four subjects with T/T genotype had no answer.