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Table 5 Association between cardiovascular parameters and the carrier status of the 14 bp indel in NCX1 intron 2

From: Hypervariable intronic region in NCX1 is enriched in short insertion-deletion polymorphisms and showed association with cardiovascular traits

      

Association testing using linear regression1

   

WT/WT

WT/

indel

indel/

indel

Additive model

Dominant model

 

Sample

n

Mean (± SD)

Mean (± SD)

Mean (± SD)

P-value

Effect (SE)

P-value

Effect (SE)

SBP (mmHg)2

HYPEST

997

140.7 (21.19)

141.4 (22.93)

168.7 (36.14)

0.31

1.50 (1.47)

0.45

1.14 (1.52)

 

CADCZ

670

132.4 (20.29)

134.1 (22.00)

135.0 (18.03)

0.44

1.43 (1.85)

0.42

1.54 (1.92)

 

Meta-analysis

1667

137.4 (21.23)

138.4 (22.80)

151.8 (31.51)

0.20

1.47 (1.15)

0.28

1.29 (1.19)

 

Healthy subjects3

1048

128.5 (5.66)

128.0 (10.53)

136.5 (9.19)

0.47

-0.71 (0.98)

0.39

-0.86 (0.99)

DBP (mmHg)2

HYPEST

993

86.9 (12.67)

87.2 (13.31)

104.3 (22.28)

0.39

0.82 (0.95)

0.57

0.55 (0.98)

 

CADCZ

669

84.2 (11.51)

84.1 (15.45)

86.7 (11.55)

0.71

0.39 (1.07)

0.73

0.38 (1.11)

 

Meta-analysis

1662

85.8 (12.29)

85.9 (14.29)

95.5 (18.59)

0.38

0.63 (0.71)

0.51

0.48 (0.74)

 

Healthy subjects3

1048

81.4 (1.41)

80.5 (7.85)

85.0 (7.07)

0.11

-1.06 (0.66)

0.08

-1.15 (0.67)

Heart rate (bpm)

CADCZ

670

75.1 (5.51)

76.2 (5.83)

69.3 (3.06)

0.15

0.79 (0.54)

0.07

1.03 (0.56)

 

Healthy subjects3

833

75.0 (8.49)

73.3 (8.06)

70.0 (0.00)

0.04

-1.61 (0.79)

0.05

-1.60 (0.80)

IMT

(mm)

CADCZ

670

0.63 (0.20)

0.65 (0.20)

0.87 (0.29)

0.20

0.03 (0.02)

0.33

0.02 (0.02)

 

CADCZ controls

413

0.58 (0.17)

0.54 (0.15)

1.20 (0.00)

0.42

-0.02 (0.02)

0.18

-0.03 (0.02)

  1. 1For association analysis with SBP and DBP regression testing for a linear trend of marker alleles was performed with age, sex and BMI as covariates. Association analysis with heart rate was performed with sex as covariate, and intima-media thickness without covariates.
  2. 2Correction for antihypertensive treatment was implemented to all treated patients as described[25].
  3. 3Pooled HYPEST and CADCZ control subjects, who had no personal history of cardiovascular disease, including essential hypertension, myocardial infarction, coronary artery disease, stroke, and had never been prescribed cardiovascular medications. Previously, no population differentiation was detected between HYPEST and CADCZ study subjects[18]
  4. n - number of individuals; IMT - Intima-media thickness; Significant differences have been highlighted in bold, p < 0.05