Hypervariable intronic region in NCX1 is enriched in short insertion-deletion polymorphisms and showed association with cardiovascular traits

Table 4 Association between cardiovascular disease and NCX1 intronic 14 bp indel rs11274804

			Minor allele		Association testing using logistic regression¹
			frequency (%)		Additive model		Dominant model
Disease	Sample	Sample size cases/ controls²	Cases	Controls	P-value	OR [95%CI]	P-value	OR [95%CI]
Essential hypertension	HYPEST	470/652	7.76	9.04	0.14	0.70 [0.44, 1.12]	0.09	0.65 [0.40, 1.06]
Coronary artery disease	CADCZ	257/413	12.45	7.02	0.0016	2.02 [1.30, 3.13]	0.0018	2.07 [1.31, 3.26]
Coronary artery disease & metabolic syndrome	CADCZ	88/361	15.07	7.64	0.0014	2.34 [1.38, 3.96]	0.0016	2.41 [1.39, 4.18]

¹Logistic regression analysis was performed with the following covariates: sex, age, BMI.
²Detailed definition of cases and controls for essential hypertension, coronary artery disease and metabolic syndrome is given in Materials and Methods, as well as in additional file 2.
Significant differences have been highlighted in bold, P < 0.05.

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