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Table 1 Phenotypic characteristics of analyzed individuals

From: Hypervariable intronic region in NCX1 is enriched in short insertion-deletion polymorphisms and showed association with cardiovascular traits

 

HYPEST

 

CADCZ

 

Healthy Eastern

Variable

Cases

Controls

Cases

Controls

European individuals1

No. of individuals

470

652

257

413

1065

Parameters (mean ± SD):

     

Age (years)2

43.9 (13.0)

39.0 (4.9)

51.2 (8.1)

49.5 (7.4)

43.7 (9.7)

Body Mass Index (BMI) (kg/m2)

28.7 (3.7)

24.4 (3.3)

27.9 (3.3)

25.3 (3.1)

24.7 (3.1)

Systolic blood pressure (SBP) (mmHg)

143.2 (17.6)

130.0 (22.7)

136.6 (19.2)

125.2 (14.0)

128.5 (12.2)

Diastolic blood pressure (DBP) (mmHg)

87.4 (10.6)

81.0 (14.6)

85.1 (11.3)

80.3 (9.3)

80.0 (8.2)

Total cholesterol (mmol/liter)

5.6 (1.1)

5.0 (1.4)

5.4 (1.0)

5.6 (1.0)

5.4 (1.1)

High-density lipoprotein (HDL) (mmol/liter)

1.5 (0.4)

1.7 (0.5)

1.2 (0.3)

1.5 (0.4)

1.5 (0.4)

Low-density lipoprotein (LDL) (mmol/liter)

3.8 (1.0)

3.3 (1.1)

3.2 (0.8)

3.4 (0.9)

3.3 (0.9)

Triacylglycerols (mmol/liter)

1.8 (1.6)

0.8 (0.3)

2.1 (1.3)

1.5 (1.1)

1.2 (1.1)

Intima media thickness (IMT)

NA

NA

0.7 (0.2)

0.6 (0.2)

NA

Heart Rate (HR) (bpm)

NA

71.0 (26.4)

76.0 (5.6)

74.8 (5.5)

74.0 (8.6)

Medication:

     

% of antihypertensive treatment

75.3%

0%

54.5%

0%

0%

% of antilipidemic treatment

20.2%

0%

58.4%

0%

0%

  1. 1Pooled HYPEST and CADCZ control subjects, who had no personal history of cardiovascular disease, including essential hypertension, myocardial infarction, coronary artery disease, stroke, and had never been prescribed antihypertensive or other cardiovascular medications. Previously, no population differentiation was detected between HYPEST and CADCZ study subjects[18]
  2. 2Cases: age at the onset of the essential hypertension (HYPEST) or coronary artery disease (CADCZ); Controls: age at the recruitment
  3. mmHg - millimeters of mercury; bpm - beats per minute; NA - not available