Figure 2
From: Genetic investigations on 8 patients affected by ring 20 chromosome syndrome
Example of the FISH results obtained for each proband on ring 20 chromosome. A) pan-telomeric probe; B) 20p (green signal) and 20q (red signal) subtelomeric specific probes; C) RCP11-939M14 and D) RCP11-358D14 BAC clones targeting CHRNA4 and KCNQ2 epilepsy genes respectively. The presence of the signals on r(20) (arrowed) demonstrates the integrity of the investigated regions. In panel C, RCP11-939M14 clone cross-hybridizes with chromosome 15.