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Table 4 Genotype distribution for the 5 LXRβ; SNPs in overweight or obese and normal weight individuals from the HELENA study and ORs [95% CI] of overweight/obesity.

From: Suggestive evidence of associations between liver X receptor β polymorphisms with type 2 diabetes mellitus and obesity in three cohort studies: HUNT2 (Norway), MONICA (France) and HELENA (Europe)

 

Genotype

Normal weight (n = 879)

Overweight/obese (n = 265)

Crude p

Adjusted OR

[95% CI]

Adjusted p

  

n

Frequency

n

Frequency

    

rs17373080

CC

427

0.49

102

0.39

    
 

CG

366

0.42

125

0.48

0.01

1.59

[1.19-2.13]

0.002

 

GG

85

0.10

36

0.14

    
 

Total

878

 

263

     

rs56151148

CC

728

0.83

233

0.88

    
 

CT

142

0.16

31

0.12

0.13a

0.72

[0.47-1.11]

0.14

 

TT

9

0.01

1

0.00

    
 

Total

879

 

265

     

rs2695121

CC

301

0.34

106

0.40

    
 

CT

430

0.49

123

0.47

0.15

0.76

[0.57-1.02]

0.071

 

TT

148

0.17

35

0.13

    
 

Total

879

 

264

     

rs2303044

CC

761

0.87

207

0.78

    
 

CT

111

0.13

53

0.20

0.003 a

1.84

[1.27-2.66]

0.001

 

TT

5

0.01

4

0.02

    
 

Total

877

 

264

     

rs3219281

CC

732

0.83

200

0.75

    
 

CT

138

0.16

59

0.22

0.01 a

1.78

[1.25-2.52]

0.001

 

TT

9

0.01

6

0.02

    
 

Total

879

 

265

     
  1. aFisher exact test. ORs and p values were adjusted for age, gender and centre. A dominant model was used to calculate the odds ratios. Significant p values are indicated in bold.