Suggestive evidence of associations between liver X receptor β polymorphisms with type 2 diabetes mellitus and obesity in three cohort studies: HUNT2 (Norway), MONICA (France) and HELENA (Europe)

Table 1 SNPs detected by sequencing the LXRβ gene.

#	rs number	Position on chromosome 19	Position from ATG	Location	Base change	MAF in sequenced individuals (n = 96)	MAF in HUNT2 controls (n = 1986)	MAF in MONICA (n = 2318)	MAF in HELENA-CSS (n = 1144)
1	rs79233036^a	55,569,984	-2692	5' near gene	C>T	0.005 (1 heterozygous subject)	0	-	-
2	rs77094157^a	55,570,236	-2440	5' near gene	C>T	0.005 (1 heterozygous subject)	NA	-	-
3	rs12972221	55,570,952	-1723	5' near gene	G>T	0.36	NA	-	-
4	rs17373080	55,571,336	-1339	5' near gene	C>G	0.37	0.35	0.31	0.32
5	rs56151148	55,571,364	-1311	5' near gene	C>T	0.05	0.08	0.09	0.08
6	rs55794952	55,571,487	-1188	5' near gene	G>T	0.005 (1 heterozygous subject)	0.007	-	-
7	rs2695121	55,572,553	-122	intron 2	C>T	0.44	0.44	0.43	0.40
8	rs55671147	55,572,866	+192	exon 4	G>A (Glu36Glu)	0.03	NA	-	-
9	rs28514894	55,573,138	+464	intron 4	C>T	0.33	0.35	-	-
10	rs2248949	55,573,981	+1306	intron 6	G>A	0.45	0.44	-	-
11	rs41432149	55,573,984	+1309	intron 6	C>T	0.36	0.35	-	-
12	rs77290536^a	55,574,080	+1405	exon 7	C>G (Pro252Arg)	0.005 (1 heterozygous subject)	0	-	-
13	rs78105260^a	55,574,374	+1700	intron 7	A>G	0.005 (1 heterozygous subject)	0.007	-	-
14	rs1405655	55,574,431	+1757	intron 7	C>T	0.36	0.35	-	-
15	rs2303045	55,574,730	+2056	intron 7	C>G	0.35	0.35	-	-
16	rs4802703	55,576,697	+4023	intron 8	A>C	0.40	0.32	-	-
17	rs2303044	55,577,013	+4339	intron 8	A>G	0.10	0.07	0.08	0.08
18	rs1052677	55,577,993	+5319	3' UTR	C>G	0.16	0.09	-	-
19	rs75967835^a	55,578,378	+5704	3' near gene	A>C	0.005 (1 heterozygous subject)	0	-	-
20	rs3219281	55,578,899	+6225	3' near gene	C>T	0.15	0.09	0.09	0.10

Positions based on NM_007121 sequence. MAF: minor allele frequency. NA: not available.
The 5 SNPs selected for association studies are indicated in bold.
^adiscovered by gene sequencing in the present study.

ISSN: 1471-2350