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Table 3 Allele associations (P < 0.05) among subgroups

From: Genes encoding critical transcriptional activators for murine neural tube development and human spina bifida: a case-control study

SNP

Gene

Ethnicity

refSNP alleles

Minor Allele

Ratio Counts

(Case, Control)

P value

Odds Ratio

95% CI

rs129986

CREBBP (CBP)

white

C/T

T

118:0, 182:10

0.008*

n/a

n/a

rs17616105

CARM1

white

C/T

C

101:17, 136:56

0.003

2.45

1.34-4.46

rs303056

TFAP2A (AP2)

white

C/G

C

16:102, 13:179

0.046

2.16

1.00-2.15

rs3798691

TFAP2A (AP2)

Hispanic

C/G

C

65:333, 29:267

0.013

1.80

1.13-2.87

  

Hispanic-FB

C/G

C

52:280, 22:208

0.036

1.76

1.03-2.98

rs533558

TFAP2A (AP2)

Hispanic-NB

A/G

G

36:30, 24:42

0.036

2.10

1.05-4.22

rs4820428

EP300 (P300)

All subjects

A/G

G

276:240, 229:259

0.038

1.30

1.01-1.67