|  |  | Age × SNP interaction | Time × SNP interaction | ||
---|---|---|---|---|---|---|
Gene | SNP (Risk allele, frequency) | Factor | Beta (95% CI) | p | Beta (95% CI) | p |
Fasting glucose b (log e [mmol/l]) | Â | Â | Â | Â | Â | Â |
   KCNJ11 | rs5219 | CC | Baseline |  |  |  |
 | (T, 0.355) | CT | 7.0 × 10-5 (-4.6 × 10-4, 6.0 × 10-4) | 0.79 | -5.3 × 10-4 (-1.3 × 10-3, 2.6 × 10-4) | 0.19 |
 |  | TT | -4.3 × 10-4 (-1.2 × 10-3, 3.3 × 10-4) | 0.27 | -6.8 × 10-4 (-1.8 × 10-3, 4.8 × 10-4) | 0.25 |
   PPARG | rs1801282 | CC | Baseline |  |  |  |
 | (C, 0.881) | CG | 8.0 × 10-5 (-5.2 × 10-4, 6.8 × 10-4) | 0.79 | -3.6 × 10-4 (-1.3 × 10-3, 5.4 × 10-4) | 0.43 |
 |  | GG | -8.8 × 10-4 (-3.0 × 10-3, 1.2 × 10-3) | 0.41 | 3.7 × 10-4 (-2.8 × 10-3, 3.6 × 10-3) | 0.82 |
   TCF7L2 | rs7903146 | CC | Baseline |  |  |  |
 | (T, 0.300) | CT | -1.2 × 10-4 (-6.3 × 10-4, 4.0 × 10-4) | 0.65 | -3.2 × 10-4 (-1.1 × 10-3, 4.5 × 10-4) | 0.41 |
 |  | TT | 7.3 × 10-4 (-1.6 × 10-4, 1.6 × 10-3) | 0.11 | 5.6 × 10-4 (-8.0 × 10-4, 1.9 × 10-3) | 0.42 |
   IGF2BP2 | rs4402960 | GG | Baseline |  |  |  |
 | (T, 0.314) | GT | -3.8 × 10-5 (-5.5 × 10-4, 4.8 × 10-4) | 0.89 | 6.3 × 10-4 (-1.5 × 10-4, 1.4 × 10-3) | 0.12 |
 |  | TT | 4.7 × 10-4 (-4.1 × 10-4, 1.4 × 10-3) | 0.30 | -4.0 × 10-4 (-1.7 × 10-3, 9.1 × 10-4) | 0.55 |
   CDKAL1 | rs10946398 | AA | Baseline |  |  |  |
 | (C, 0.308) | AC | 4.9 × 10-5 (-4.7 × 10-4, 5.7 × 10-4) | 0.85 | 2.1 × 10-4 (-5.7 × 10-4, 9.9 × 10-4) | 0.60 |
 |  | CC | -3.3 × 10-4 (-1.2 × 10-3, 5.0 × 10-4) | 0.43 | -3.6 × 10-4 (-1.6 × 10-3, 9.1 × 10-4) | 0.58 |
   SLC30A8 | rs13266634 | CC | Baseline |  |  |  |
 | (C, 0.696) | CT | 2.4 × 10-5 (-4.9 × 10-4, 5.4 × 10-4) | 0.93 | 1.4 × 10-4 (-6.4 × 10-4, 9.1 × 10-4) | 0.73 |
 |  | TT | 8.0 × 10-4 (-5.2 × 10-5, 1.7 × 10-3) | 0.07 | -1.2 × 10-4 (-1.4 × 10-3, 1.2 × 10-3) | 0.86 |
   HHEX | rs1111875 | GG | Baseline |  |  |  |
 | (G, 0.578) | GA | 6.1 × 10-4 (6.3 × 10-5, 1.2 × 10-3) | 0.03* | -2.3 × 10-4 (-1.0 × 10-3, 6.0 × 10-4) | 0.59 |
 |  | AA | -2.3 × 10-4 (-9.3 × 10-4, 4.8 × 10-4) | 0.53 | 2.4 × 10-4 (-8.2 × 10-4, 1.3 × 10-3) | 0.65 |
BMI b (log e [kg/m 2 ]) | Â | Â | Â | Â | Â | Â |
   FTO | rs9939609 | TT | Baseline |  |  |  |
 | (A, 0.402) | TA | 2.6 × 10-4 (-4.7 × 10-4, 9.9 × 10-4) | 0.49 | 2.1 × 10-5 (-7.7 × 10-4, 8.1 × 10-4) | 0.96 |
 |  | AA | -2.0 × 10-5 (-1.0 × 10-3, 9.9 × 10-4) | 0.97 | -2.8 × 10-4 (-1.4 × 10-3, 8.1 × 10-4) | 0.61 |