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Table 4 Results of longitudinal association analyses of fasting glucose and BMI.a

From: The longitudinal association of common susceptibility variants for type 2 diabetes and obesity with fasting glucose level and BMI

   

Age × SNP interaction

Time × SNP interaction

Gene

SNP (Risk allele, frequency)

Factor

Beta (95% CI)

p

Beta (95% CI)

p

Fasting glucose b (log e [mmol/l])

      

   KCNJ11

rs5219

CC

Baseline

   
 

(T, 0.355)

CT

7.0 × 10-5 (-4.6 × 10-4, 6.0 × 10-4)

0.79

-5.3 × 10-4 (-1.3 × 10-3, 2.6 × 10-4)

0.19

  

TT

-4.3 × 10-4 (-1.2 × 10-3, 3.3 × 10-4)

0.27

-6.8 × 10-4 (-1.8 × 10-3, 4.8 × 10-4)

0.25

   PPARG

rs1801282

CC

Baseline

   
 

(C, 0.881)

CG

8.0 × 10-5 (-5.2 × 10-4, 6.8 × 10-4)

0.79

-3.6 × 10-4 (-1.3 × 10-3, 5.4 × 10-4)

0.43

  

GG

-8.8 × 10-4 (-3.0 × 10-3, 1.2 × 10-3)

0.41

3.7 × 10-4 (-2.8 × 10-3, 3.6 × 10-3)

0.82

   TCF7L2

rs7903146

CC

Baseline

   
 

(T, 0.300)

CT

-1.2 × 10-4 (-6.3 × 10-4, 4.0 × 10-4)

0.65

-3.2 × 10-4 (-1.1 × 10-3, 4.5 × 10-4)

0.41

  

TT

7.3 × 10-4 (-1.6 × 10-4, 1.6 × 10-3)

0.11

5.6 × 10-4 (-8.0 × 10-4, 1.9 × 10-3)

0.42

   IGF2BP2

rs4402960

GG

Baseline

   
 

(T, 0.314)

GT

-3.8 × 10-5 (-5.5 × 10-4, 4.8 × 10-4)

0.89

6.3 × 10-4 (-1.5 × 10-4, 1.4 × 10-3)

0.12

  

TT

4.7 × 10-4 (-4.1 × 10-4, 1.4 × 10-3)

0.30

-4.0 × 10-4 (-1.7 × 10-3, 9.1 × 10-4)

0.55

   CDKAL1

rs10946398

AA

Baseline

   
 

(C, 0.308)

AC

4.9 × 10-5 (-4.7 × 10-4, 5.7 × 10-4)

0.85

2.1 × 10-4 (-5.7 × 10-4, 9.9 × 10-4)

0.60

  

CC

-3.3 × 10-4 (-1.2 × 10-3, 5.0 × 10-4)

0.43

-3.6 × 10-4 (-1.6 × 10-3, 9.1 × 10-4)

0.58

   SLC30A8

rs13266634

CC

Baseline

   
 

(C, 0.696)

CT

2.4 × 10-5 (-4.9 × 10-4, 5.4 × 10-4)

0.93

1.4 × 10-4 (-6.4 × 10-4, 9.1 × 10-4)

0.73

  

TT

8.0 × 10-4 (-5.2 × 10-5, 1.7 × 10-3)

0.07

-1.2 × 10-4 (-1.4 × 10-3, 1.2 × 10-3)

0.86

   HHEX

rs1111875

GG

Baseline

   
 

(G, 0.578)

GA

6.1 × 10-4 (6.3 × 10-5, 1.2 × 10-3)

0.03*

-2.3 × 10-4 (-1.0 × 10-3, 6.0 × 10-4)

0.59

  

AA

-2.3 × 10-4 (-9.3 × 10-4, 4.8 × 10-4)

0.53

2.4 × 10-4 (-8.2 × 10-4, 1.3 × 10-3)

0.65

BMI b (log e [kg/m 2 ])

      

   FTO

rs9939609

TT

Baseline

   
 

(A, 0.402)

TA

2.6 × 10-4 (-4.7 × 10-4, 9.9 × 10-4)

0.49

2.1 × 10-5 (-7.7 × 10-4, 8.1 × 10-4)

0.96

  

AA

-2.0 × 10-5 (-1.0 × 10-3, 9.9 × 10-4)

0.97

-2.8 × 10-4 (-1.4 × 10-3, 8.1 × 10-4)

0.61

  1. a BMI outcome analyses were conducted on data from unrelated participants aged 18-80 years (n = 2,864). Fasting glucose outcome analyses were conducted on data from the subset of non-diabetic participants (n = 2,583). Results are for age × SNP and time × SNP interaction terms with co-dominant genetic models.
  2. b Phenotype adjustments:
  3. Fasting glucose: sex, age, BMI, age at first survey, time of survey
  4. BMI: sex, age, age × sex, smoking status, age at first survey, time of survey
  5. *p < 0.05