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Table 2 SNPs information and logistic analysis for CACNG6

From: Association of CACNG6 polymorphisms with aspirin-intolerance asthmatics in a Korean population

SNP/Haplotype Allele change Position Frequency Hetero-zygosity Frequencya HWE Co-dominant Dominant Recessive
      AIA ATA AIA ATA OR(95%CI) P P corr OR(95%CI) P P corr OR(95%CI) P P corr
rs251850 T > C Promoter 0.176 0.29 0.176 0.177 0.904 0.139 0.97 (0.64-1.49) 0.9 - 0.93(0.58-1.49) 0.75 - 1.49(0.38-5.94) 0.57 -
rs4806481 C > T Intron 0.482 0.499 0.451 0.488 0.766 0.461 0.89(0.64-1.22) 0.45 - 0.84(0.52-1.37) 0.49 - 0.86(0.50-1.49) 0.6 -
rs158196 A > G Intron 0.35 0.455 0.363 0.348 0.499 0.537 0.99(0.72-1.37) 0.96 - 0.95(0.60-1.49) 0.82 - 1.08(0.57-2.04) 0.81 -
rs158199 G > A Intron 0.24 0.364 0.255 0.233 0.474 0.124 1.03(0.73-1.46) 0.87 - 1.03(0.66-1.62) 0.88 - 1.05(0.45-2.41) 0.92 -
rs192808 C > T Intron 0.058 0.11 0.103 0.045 0.931 0.899 2.88(1.60-5.17) 0.0004 0.0029 2.99(1.62-5.54) 0.0005 0.0036 6.11(0.28-131.25) 0.25 -
rs450227 C > T Intron 0.146 0.25 0.167 0.145 0.552 0.444 1.1(0.71-1.70) 0.67 - 1.13(0.69-1.83) 0.63 - 0.98(0.19-5.01) 0.98 -
rs2291068 T > C Exon 0.199 0.319 0.225 0.192 0.645 0.562 1.08(0.73-1.58) 0.71 - 1.04(0.66-1.64) 0.88 - 1.43(0.52-3.96) 0.49 -
rs459247 G > A Exon 0.5 0.5 0.426 0.515 0.558 0.542 0.75(0.55-1.03) 0.07 0.54 0.66(0.41-1.07) 0.09 0.68 0.71(0.41-1.22) 0.21 -
CACNG6_BL1_ht1    0.339 0.448 0.324 0.338 0.884 0.665 0.97(0.70-1.36) 0.87 - 0.94(0.60-1.47) 0.78 - 1.03(0.51-2.11) 0.93 -
CACNG6_BL1_ht2    0.207 0.328 0.211 0.202 0.142 0.095 0.97(0.67-1.41) 0.88 - 0.93(0.58-1.47) 0.74 - 1.14(0.46-2.80) 0.78 -
CACNG6_BL1_ht3    0.153 0.259 0.152 0.154 0.62 0.242 0.94(0.60-1.46) 0.77 - 0.87(0.53-1.43) 0.58 - 1.72(0.42-7.09) 0.45 -
CACNG6_BL1_ht4    0.097 0.175 0.083 0.104 0.705 0.472 0.8(0.46-1.38) 0.41 - 0.78(0.43-1.41) 0.41 - 0.77(0.09-6.70) 0.82 -
CACNG6_BL1_ht5    0.082 0.151 0.054 0.093 0.565 0.677 0.57(0.29-1.12) 0.1 0.76 0.58(0.29-1.15) 0.12 0.85 . 0.99 -
CACNG6_BL1_ht6    0.057 0.107 0.093 0.045 0.3 0.899 2.57(1.39-4.73) 0.003 0.02 2.81(1.51-5.24) 0.001 0.0087 . 0.99 -
CACNG6_BL2_ht1    0.495 0.5 0.422 0.509 0.447 0.6 0.75(0.55-1.03) 0.07 0.52 0.65(0.40-1.04) 0.07 0.52 0.73(0.42-1.26) 0.26 -
CACNG6_BL2_ht2    0.29 0.412 0.338 0.283 0.238 0.538 1.31(0.94-1.83) 0.11 0.77 1.66(1.06-2.60) 0.03 0.2 0.93(0.43-2.04) 0.86 -
CACNG6_BL2_ht3    0.13 0.226 0.152 0.129 0.785 0.173 1.1(0.69-1.74) 0.68 - 1.07(0.65-1.77) 0.78 - 1.76(0.30-10.15) 0.53 -
CACNG6_BL2_ht4    0.068 0.127 0.069 0.063 0.457 0.567 0.93(0.49-1.77) 0.83 - 0.96(0.50-1.84) 0.89 - . 0.99 -
  1. aThe frequency of SNP indicates the minor allele frequency.
  2. HWE, Hardy-Weinberg equilibrium; P corr, corrected P-value using multiple testing corrections.
  3. AIA, aspirin-intolerant asthma; ATA, aspirin-tolerant asthma; AA, amino acid; MAF, minor allele frequency; OR, odds ratio; CI, confidence interval