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Table 2 SNPs information and logistic analysis for CACNG6

From: Association of CACNG6 polymorphisms with aspirin-intolerance asthmatics in a Korean population

SNP/Haplotype

Allele change

Position

Frequency

Hetero-zygosity

Frequencya

HWE

Co-dominant

Dominant

Recessive

     

AIA

ATA

AIA

ATA

OR(95%CI)

P

P corr

OR(95%CI)

P

P corr

OR(95%CI)

P

P corr

rs251850

T > C

Promoter

0.176

0.29

0.176

0.177

0.904

0.139

0.97 (0.64-1.49)

0.9

-

0.93(0.58-1.49)

0.75

-

1.49(0.38-5.94)

0.57

-

rs4806481

C > T

Intron

0.482

0.499

0.451

0.488

0.766

0.461

0.89(0.64-1.22)

0.45

-

0.84(0.52-1.37)

0.49

-

0.86(0.50-1.49)

0.6

-

rs158196

A > G

Intron

0.35

0.455

0.363

0.348

0.499

0.537

0.99(0.72-1.37)

0.96

-

0.95(0.60-1.49)

0.82

-

1.08(0.57-2.04)

0.81

-

rs158199

G > A

Intron

0.24

0.364

0.255

0.233

0.474

0.124

1.03(0.73-1.46)

0.87

-

1.03(0.66-1.62)

0.88

-

1.05(0.45-2.41)

0.92

-

rs192808

C > T

Intron

0.058

0.11

0.103

0.045

0.931

0.899

2.88(1.60-5.17)

0.0004

0.0029

2.99(1.62-5.54)

0.0005

0.0036

6.11(0.28-131.25)

0.25

-

rs450227

C > T

Intron

0.146

0.25

0.167

0.145

0.552

0.444

1.1(0.71-1.70)

0.67

-

1.13(0.69-1.83)

0.63

-

0.98(0.19-5.01)

0.98

-

rs2291068

T > C

Exon

0.199

0.319

0.225

0.192

0.645

0.562

1.08(0.73-1.58)

0.71

-

1.04(0.66-1.64)

0.88

-

1.43(0.52-3.96)

0.49

-

rs459247

G > A

Exon

0.5

0.5

0.426

0.515

0.558

0.542

0.75(0.55-1.03)

0.07

0.54

0.66(0.41-1.07)

0.09

0.68

0.71(0.41-1.22)

0.21

-

CACNG6_BL1_ht1

  

0.339

0.448

0.324

0.338

0.884

0.665

0.97(0.70-1.36)

0.87

-

0.94(0.60-1.47)

0.78

-

1.03(0.51-2.11)

0.93

-

CACNG6_BL1_ht2

  

0.207

0.328

0.211

0.202

0.142

0.095

0.97(0.67-1.41)

0.88

-

0.93(0.58-1.47)

0.74

-

1.14(0.46-2.80)

0.78

-

CACNG6_BL1_ht3

  

0.153

0.259

0.152

0.154

0.62

0.242

0.94(0.60-1.46)

0.77

-

0.87(0.53-1.43)

0.58

-

1.72(0.42-7.09)

0.45

-

CACNG6_BL1_ht4

  

0.097

0.175

0.083

0.104

0.705

0.472

0.8(0.46-1.38)

0.41

-

0.78(0.43-1.41)

0.41

-

0.77(0.09-6.70)

0.82

-

CACNG6_BL1_ht5

  

0.082

0.151

0.054

0.093

0.565

0.677

0.57(0.29-1.12)

0.1

0.76

0.58(0.29-1.15)

0.12

0.85

.

0.99

-

CACNG6_BL1_ht6

  

0.057

0.107

0.093

0.045

0.3

0.899

2.57(1.39-4.73)

0.003

0.02

2.81(1.51-5.24)

0.001

0.0087

.

0.99

-

CACNG6_BL2_ht1

  

0.495

0.5

0.422

0.509

0.447

0.6

0.75(0.55-1.03)

0.07

0.52

0.65(0.40-1.04)

0.07

0.52

0.73(0.42-1.26)

0.26

-

CACNG6_BL2_ht2

  

0.29

0.412

0.338

0.283

0.238

0.538

1.31(0.94-1.83)

0.11

0.77

1.66(1.06-2.60)

0.03

0.2

0.93(0.43-2.04)

0.86

-

CACNG6_BL2_ht3

  

0.13

0.226

0.152

0.129

0.785

0.173

1.1(0.69-1.74)

0.68

-

1.07(0.65-1.77)

0.78

-

1.76(0.30-10.15)

0.53

-

CACNG6_BL2_ht4

  

0.068

0.127

0.069

0.063

0.457

0.567

0.93(0.49-1.77)

0.83

-

0.96(0.50-1.84)

0.89

-

.

0.99

-

  1. aThe frequency of SNP indicates the minor allele frequency.
  2. HWE, Hardy-Weinberg equilibrium; P corr, corrected P-value using multiple testing corrections.
  3. AIA, aspirin-intolerant asthma; ATA, aspirin-tolerant asthma; AA, amino acid; MAF, minor allele frequency; OR, odds ratio; CI, confidence interval
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BMC Medical Genetics

ISSN: 1471-2350

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