Skip to main content

Table 2 miRNA target predictions for rs62093482

From: A possible role for miRNA silencing in disease phenotype variation in Swedish transthyretin V30M carriers

wt (C) allele Identified with Predicted binding to wt allele Predicted binding to polymorphic allele
hsa-miR-593 MicroInspector RegRNA/RNAhybrid RegRNA/RNAhybrid
hsa-miR-492 MicroInspector RNAhybrid RNAhybrid
hsa-miR-1245 PITA RNAhybrid RNAhybrid
hsa-miR-581 PITA RegRNA/RNAhybrid RNAhybrida
hsa-miR-142-3p PITA RegRNA/RNAhybrid RNAhybrida
Polymorphic (T) allele Identified with Predicted binding to wt allele Predicted binding to polymorphic allele
hsa-miR-643 MicroInspector/PITA RNAhybridb RegRNA/RNAhybrid
hsa-miR-337-3p MicroInspector RNAhybridb RegRNA/RNAhybrid
hsa-miR-384 MicroInspector RegRNA/RNAhybrid RegRNA/RNAhybrid
hsa-miR-622 PITA   RegRNA/RNAhybrid
hsa-miR-325 PITA RNAhybridb RegRNA/RNAhybrid
  1. Underlined; predictions unique for wt or polymorphic target respectively in the subsequent validation procedure. In bold, miRNA target predictions that fulfil the criteria. aPredicted for polymorphic target with only slightly weaker binding, C:G > U:G. bDecreased binding specificity when predicted to wt target leading to reduced thermodynamic properties.