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Table 3 Univariable and multivariable associations of obesity and diabetes SNPs with small for gestational age at term (genotype data)

From: Obesity and diabetes genes are associated with being born small for gestational age: Results from the Auckland Birthweight Collaborative study

SNP

genotype

n

Univariable OR

Multivariable* OR

rs9939609

A

61

0.91 (0.50 - 1.64)

0.96 (0.47 - 1.94)

FTO

AT

265

1.54 (1.07 - 2.22)

1.30 (0.85 - 1.99)

 

T

218

Ref

Ref

rs864745

A

145

Ref

Ref

JAZF1

AG

346

1.57 (1.03 - 2.39)

1.43 (0.88 - 2.32)

 

G

136

1.18 (0.73 - 1.91)

1.04 (0.59 - 1.83)

rs5219

C

223

Ref

Ref

KCNJ11

CT

252

1.64 (1.13 - 2.37)

1.50 (0.98 - 2.31)

 

T

76

1.59 (0.94 - 2.69)

1.90 (1.04 - 3.50)

rs6265

A

17

2.84 (1.03 - 7.87)

3.29 (1.08 - 9.99)

BDNF

AG

142

1.17 (0.79 - 1.74)

1.18 (0.74 - 1.90)

 

G

347

Ref

Ref

rs925946

G

232

Ref

Ref

BDNF

T

66

0.84 (0.48 -1.46)

0.71 (0.38 - 1.34)

 

GT

249

0.58 (0.40 -0.83)

0.58 (0.38 - 0.89)

rs6602024

A

0

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PFKP

GA

116

0.68 (0.44 - 1.04)

0.57 (0.35 - 0.95)

 

G

435

Ref

Ref

rs10508503

C

447

Ref

Ref

PTER

CT

82

0.55 (0.33 - 0.91)

0.51 (0.28 - 0.91)

 

T

3

2.49 (0.22 - 27.7)

1.19 (0.09 -16.58)

rs10913469

C

13

2.94 (0.89 - 9.73)

2.54 (0.65 - 9.97)

SEC16B

TC

367

0.74 (0.50 - 1.09)

0.56 (0.35 - 0.89)

 

T

158

Ref

Ref

  1. * Multivariable model controls for gestational age, gender, socio-economic status, age mother left school, marital status, attendance at antenatal classes, primiparity, maternal smoking during pregnancy, marijuana use during pregnancy, maternal height and weight, maternal age at index pregnancy and maternal hypertension.