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Table 2 Univariable and multivariable associations of obesity and diabetes SNPs with small for gestational age at term (allelic and genotypic) data

From: Obesity and diabetes genes are associated with being born small for gestational age: Results from the Auckland Birthweight Collaborative study

        

Univariable analysis

Multivariable analysis*

Gene

SNP

alleles

Minor allele

Risk allele associated with SGA in ABC samples

Risk allele associated with obesity/diabetes

Minor allele frequency

Minor allele homozygote frequency

genotypic p-value

allelic p-value

Odds ratio

95% CI

Genotypic p-value

allelic

p-value

Odds ratio

95% CI

FTO

rs9939609

AT

A

A

A (obesity)

33.8

11.4

0.03

0.42

1.11

0.86-1.43

0.40

0.63

1.07

0.80-1.44

JAZF1

rs864745

AG

G

G

A (diabetes)

48.3

26.7

0.09

0.64

1.06

0.83-1.36

0.26

0.98

1

0.75-1.32

KCNJ11

rs5219

CT

T

T

T (diabetes)

33.7

12.3

0.02

0.03

1.32

1.03-1.70

0.061

0.03

1.36

1.02-1.82

LPL

rs3200218

GA

G

A

A (obesity)

26.3

5.5

0.20

0.06

0.76

0.56-1.02

0.21

0.09

0.74

0.53-1.04

PFKP

rs6602024

GA

A

G

A (obesity)

12.0

0

0.08

0.13

0.73

0.49-1.10

0.03

0.06

0.64

0.40-1.02

PTER

rs10508503

CT

T

C

C (obesity)

9.8

0.5

0.04

0.06

0.64

0.41-1.02

0.07

0.04

0.58

0.34-0.98

SEC16B

rs10913469

TC

C

T

C (obesity)

18.0

1.6

0.05

0.82

0.96

0.70-1.33

0.01

0.22

0.79

0.54-1.15

BDNF

rs6265

AG

A

A

G (obesity)

16.2

2.2

0.11

0.10

1.33

0.95-1.85

0.10

0.07

1.43

0.98-2.09

BDNF

rs925946

GT

T

G

T (obesity)

30.7

11.1

0.01

0.08

0.79

0.61-1.02

0.043

0.06

0.75

0.56-1.01

  1. *Multivariable model controls for gestational age, gender, socio-economic status, age mother left school, marital status, attendance at antenatal classes, primiparity, maternal smoking during pregnancy, marijuana use during pregnancy, maternal height and weight, maternal age at index pregnancy and maternal hypertension