Table 3 Distribution of Genotypes for Furin Variable in Hypertensives and Normotensives
From: Associations between genetic variations in the FURIN gene and hypertension
Population | Variants | Genotypes | NT | HT | Additive model | χ2 | P |
|---|---|---|---|---|---|---|---|
n(%) | n(%) | OR(95%CI) | |||||
CC | 315(65.6) | 290(65.3) | |||||
CT | 143(29.8) | 134(30.2) | 1.1 (0.87-1.391) | 0.018 | 0.991* | ||
-7315C > T | TT | 22(4.8) | 20(4.5) | 0.424† | |||
rs4932178 | |||||||
CC CT+TT | 315(65.6) | 290(65.3) | 0.01 | 0.921* | |||
165(34.6) | 154 (34.7) | 1.132 (0.853-1.503) | 0.391† | ||||
GG | 171(35.7) | 145(30.27) | |||||
5604G > C | GC | 239(49.9) | 219(45.72) | 1.084 (0.891-1.319) | 2.286 | 0.319* | |
rs6226 | CC | 69(14.41) | 79(16.49) | 0.42† | |||
Kazakh Chinese | CG CG+GG | 171(35.7) | 145(30.27) | 1.031 (0.776-1.369) | 0.9 | 0.343* | |
308(50.1) | 298(46.76) | 0.834† | |||||
CC | 362(74.9) | 322(72) | |||||
6262C > T | CT | 113(23.4) | 113(25.3) | 1.284 (0.981-1.681) | 1.748 | 0.417* | |
rs6227 | TT | 8(1.7) | 12(2.7) | 0.69† | |||
CT vs CT+TT | 362(74.9) | 322(72) | 1.28 (0.945-1.733) | 1.012 | 0.313* | ||
121(25.1) | 125(28) | 0.111† | |||||
CC | 369(76.4) | 310(45.7) | |||||
1970C > G | CG | 106(21.9) | 121(27.4) | 1.451 (1.106-1.905) | 4.784 | 0.091* | |
rs2071410 | GG | 8(1.7) | 11(2.5) | 0.008† | |||
CG vs CG+GG | 369(76.4) | 310(45.7) | 1.496 (1.103-2.028) | 4.636 | 0.031* | ||
114(22.6) | 132(29.9) | 0.01† | |||||
CC | 322(67.9) | 472(63.4) | |||||
Replication (Uygur Chinese) | 1970C > G | CG | 140(29.5) | 234(31.4) | 1.327 (1.07-1.646) | 6.323 | 0.042* |
rs2071410 | GG | 12(2.5) | 39(5.2) | 0.01† | |||
CG vs CG+GG | 322(67.9) | 472(63.4) | 1.307 (1.015-1.681) | 2.672 | 0.102* | ||
160(32) | 273(36.6) | 0.038† |