Table 1 Top-ranked SNPs in each Initial Study (CAMP/Illumina or CAMP Trio p-value < 1E-05)
From: Asthma-susceptibility variants identified using probands in case-control and family-based analyses
| Â | Â | Â | Rank | Discovery P-values | Â | Stage 1 | Stage 2 | Â | |||
|---|---|---|---|---|---|---|---|---|---|---|---|
SNP | CHR | BP | CAMP/Illumina | CAMP Trio | CAMP/Illumina | CAMP Trio | Replication Attempted? | CR | FHS | CAP | Liptak P-value* |
Top CAMP/Illumina | |||||||||||
rs2548659 | 5 | 59419643 | 1 | 3122 | 2.07E-07 | 5.9E-03 | yes | 0.064 | NA | 0.15 | 0.035 |
rs1588265 | 5 | 59405551 | 2 | 5000 | 5.11E-07 | 9.4E-03 | reported in [15] | - | - | - | - |
rs983280 | 5 | 59480894 | 3 | 10253 | 5.71E-07 | 0.019 | yes | 0.094 | 5.7E-03 | NA | 3.3E-03 |
rs11778371 | 8 | 27375822 | 4 | 2947 | 7.92E-07 | 5.6E-03 | yes | 0.29 | - | - | - |
rs1544791 | 5 | 59474839 | 5 | 10852 | 1.16E-06 | 0.020 | yes/reported in [15] | 0.15 | - | - | - |
rs684909 | 11 | 35843495 | 6 | 7849 | 3.12E-06 | 0.015 | yes | 0.99 | - | - | - |
rs12725071 | 1 | 105022488 | 7 | 306415 | 4.52E-06 | 0.57 | no | - | - | - | - |
rs17219773 | 4 | 61926823 | 8 | 11376 | 4.56E-06 | 0.021 | yes | 0.83 | - | - | - |
rs12930287 | 16 | 64495907 | 9 | 228338 | 4.80E-06 | 0.42 | no | - | - | - | - |
rs11751990 | 6 | 130829469 | 10 | 19852 | 4.97E-06 | 0.037 | yes | 0.018 | 0.81 | 0.43 | 0.21 |
rs2761647 | 23 | 95159314 | 11 | NA | 5.83E-06 | NA | no | - | - | - | - |
rs12724129 | 1 | 11880226 | 12 | 43354 | 6.83E-06 | 0.082 | no | - | - | - | - |
rs7765374 | 6 | 87001318 | 13 | 8269 | 7.34E-06 | 0.015 | yes | 0.18 | - | - | - |
rs2910830 | 5 | 59502960 | 14 | 16890 | 7.79E-06 | 0.032 | yes | 0.069 | 0.061 | NA | 0.016 |
rs9318942 | 13 | 82928515 | 15 | 34248 | 8.72E-06 | 0.065 | no | - | - | - | - |
Top CAMP Trio | |||||||||||
rs1288548 | 4 | 186536979 | 4955 | 1 | 8.6E-03 | 8.7E-07 | yes | 0.24 | - | - | - |
rs261137 | 5 | 4414120 | 1068 | 2 | 1.8E-03 | 1.2E-06 | yes | 0.053 | 0.26 | 0.27 | 0.049 |
rs12734338 | 1 | 200736346 | NA | 3 | NA | 1.7E-06 | no | - | - | - | - |
rs1048329 | 4 | 186536752 | 1637 | 4 | 2.8E-03 | 3.1E-06 | yes | 0.29 | - | - | - |
rs261159 | 5 | 4396987 | 212 | 5 | 3.3E-04 | 3.4E-06 | yes | 0.086 | 0.29 | 0.27 | 0.072 |
rs12247820 | 10 | 53272196 | 558 | 6 | 9.0E-04 | 4.2E-06 | yes | 0.74 | - | - | - |
rs12743401 | 1 | 200743271 | NA | 7 | NA | 4.2E-06 | no | - | - | - | - |
rs261119 | 5 | 4418468 | 4995 | 8 | 8.7E-03 | 4.2E-06 | yes | 0.44 | - | - | - |
rs1039603 | 5 | 4345616 | 309 | 9 | 4.8E-04 | 5.0E-06 | yes | 0.063 | 0.32 | NA | 0.079 |
rs2777899 | 17 | 55187173 | 828 | 10 | 1.4E-03 | 6.1E-06 | yes | 0.34 | - | - | - |
rs261125 | 5 | 4422887 | 3764 | 11 | 6.5E-03 | 6.6E-06 | yes | 0.62 | - | - | - |
rs13267437 | 8 | 4183474 | 20383 | 12 | 0.037 | 9.5E-06 | no | - | - | - | - |
rs9463425 | 6 | 48620994 | 79984 | 13 | 0.15 | 9.7E-06 | no | - | - | - | - |