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Table 3 Association analysis for the relationship between validated SNPs in the explored candidate genes and quantitative variables of insulin resistance in PCOS with genetic effect sizes estimates derived for an additive genetic model (MC4R rs2229616 dominant genetic model) for the minor allele (see also Table 1).

From: Large effects on body mass index and insulin resistance of fat mass and obesity associated gene (FTO) variants in patients with polycystic ovary syndrome (PCOS)

  fasting insulin [mU/l] HOMA-IR [μmol/lxmmol/l2] AUCI [mUxh/l]
gene (SNP) minor allele β 95% CI p β 95% CI p β 95% CI p
FTO (rs9939609) A 3.25 (1.32;5.18) 0.001* 0.76 (0.29;1.23) 0.002* 35.92 (9.63;62.21) 0.01
INSIG2 (rs7566605) C 0.85 (-1.21;2.90) 0.42 0.33 (-0.18;0.83) 0.21 12.92 (-14.83;40.68) 0.36
TCF7L2 (rs7903146) T -0.23 (-2.40;1.93) 0.83 -0.13 (-0.66;0.40) 0.63 -5.18 (-34.27;23.91) 0.73
MC4R (rs2229616) T 3.20 (-4.67;11.07) 0.43 -0.46 (-2.45;1.53) 0.65 -8.25 (-117.9;101.4) 0.88
MC4R (rs17782313) C 1.10 (-1.08;3.28) 0.32 0.17 (-0.36;0.70) 0.54 4.52 (-25.02;34.06) 0.76
MC4R (rs12970134) A 1.07 (-1.03;3.18) 0.32 0.20 (-0.31;0.71) 0.45 1.23 (-27.21;29.68) 0.93
  1. SNP = single nucleotide polymorphism; HOMA-IR = homeostasis model assessment for insulin resistance; AUCI = area under the curve of insulin response
  2. *both associations would have been "significant" at the alpha = 0.10 level if correction for multiple testing would have been applied resulting in adjusted p-values of 0.062 for rs9939609 and fasting insulin and 0.099 for rs9939609 and HOMA-IR