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Table 2 Association analysis for the relationship between validated SNPs in the explored candidate genes and quantitative metabolic/obesity related variables in PCOS with genetic effect sizes estimates derived for an additive genetic (MC4R rs2229616 dominant genetic model) for the minor allele (see also Table 1).

From: Large effects on body mass index and insulin resistance of fat mass and obesity associated gene (FTO) variants in patients with polycystic ovary syndrome (PCOS)

  body weight [kg] BMI [kg/m2] waist [cm]
gene (SNP) minor allele β 95% CI p β 95% CI p β 95% CI p
FTO (rs9939609) A 4.60 (0.97;8.22) 0.01 1.56 (0.34;2.78) 0.01 3.49 (0.62;6.37) 0.02
INSIG2 (rs7566605) C -1.38 (-5.23;2.48) 0.48 -0.35 (-1.66;0.95) 0.59 -1.89 (-4.92;1.15) 0.22
TCF7L2 (rs7903146) T -4.18 (-8.20;-0.15) 0.04 -1.35 (-2.71;0.01) 0.05 -3.43 (-6.63;-0,24) 0.04
MC4R (rs2229616) T -2.12 (-16.88;12.63) 0.78 -0.91 (-5.88;4.06) 0.72 1.14 (-10.01;12.29) 0.84
MC4R (rs17782313) C 0.33 (-3.75;4.42) 0.87 -0.01 (-1.36;1.39) 0.98 0.54 (-2.73;3.81) 0.75
MC4R (rs12970134) A 0.20 (-3.74;4.14) 0.92 -0.12 (-1.45;1.21) 0.86 0.52 (-2,64;3.69) 0.75
  1. SNP = single nucleotide polymorphism; BMI = body mass index