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Table 3 Associations of the four candidate SNPs with generalized Aggressive Periodontitis (gAgP) in the Greifswald cohort

From: Replication of the association of chromosomal region 9p21.3with generalized aggressive periodontitis (gAgP) using an independent case-control cohort

  

Recessive model

Multiplicative model

Dominant model

 

SNP ID

P

OR

95% CI

P

OR

95% CI

P

OR

95% CI

Unadjusted analysis

rs2891168

3.20 × 10-01

1.27

0.79-2.03

4.92 × 10-02

1.33

1.00-1.77

2.89 × 10 -02

1.71

1.06-2.77

 

rs1333042

3.21 × 10-01

1.27

0.80-2.01

8.46 × 10-02

1.29

0.97-1.71

7.04 × 10-02

1.56

0.96-2.54

 

rs1333048

1.25 × 10-01

1.43

0.91-2.26

3.95 × 10 -02

1.35

1.02-1.80

6.64 × 10-02

1.57

0.97-2.55

 

rs496892

1.05 × 10-01

1.55

0.90-2.63

1.38 × 10 -02

1.47

1.09-2.00

2.03 × 10-02

1.71

1.09-2.70

Adjusted analysis

rs2891168

3.18 × 10-01

1.303

0.77-2.19

6.44 × 10-02

1.35

0.98-1.85

4.73 × 10 -02

1.70

1.01-2.88

 

rs1333042

2.88 × 10-01

1.321

0.79-2.21

9.51 × 10-02

1.31

0.95-1.80

9.99 × 10-02

1.56

0.92-2.64

 

rs1333048

1.18 × 10-01

1.498

0.90-2.49

4.22 × 10 -02

1.39

1.01-1.91

7.95 × 10-02

1.60

0.95-2.72

 

rs496892

2.20 × 10-01

1.43

0.81-2.55

4.51 × 10 -02

1.41

1.01-1.98

4.94 × 10-02

1.65

1.00-2.72

  1. Association statistics are shown for cases consisting of individuals affected with gAgP and controls consisting of individuals unaffected by gAgP. OR: Odds Ratio; 95% CI: 95% Confidence Intervals; P: p-values obtained by logistic regression using PLINK v1.06 [23]. Values are given before and after adjustment for the covariates smoking and gender. The parameters for the genetic models producing the strongest significant associations are given in boldface for each SNP for adjusted as well as unadjusted analyses.
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BMC Medical Genetics

ISSN: 1471-2350

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