Table 3 HFE genotype distribution according to etiology and mortality
From: Hereditary Hemochromatosis (HFE) genotypes in heart failure: Relation to etiology and prognosis
Variant | Genotype | Distribution | IHD (n = 332) | Hypertension (n = 61) | DCM (n = 108) | Valve disease (n = 42) | Other (n = 57) | Unknown (n = 67) | Deceased (n = 328) (%) |
|---|---|---|---|---|---|---|---|---|---|
C282Y | Non-carrier | 594 | 303 (51.0) | 51 (8.6) | 93 (15.7) | 38 (6.4) | 49 (8.3) | 60 (10.1) | 290 (48.8) |
Carrier | 73 | 29 (39.7) | 10 (13.7) | 15 (20.6) | 4 (5.5) | 8 (11.0) | 7 (9.6) | 38 (52.0) | |
H63D | Non-carrier | 523 | 268 (51.2) | 46 (8.8) | 80 (15.3) | 35 (6.7) | 39 (7.5) | 55 (10.5) | 263 (50.3) |
Carrier | 144 | 64 (44.4) | 15 (10.4) | 28 (19.4) | 7 (4.9) | 18 (12.5) | 12 (8.3) | 65 (45.1) | |
S65C | Non-carrier | 641 | 318 (49.6) | 59 (9.2) | 104 (16.2) | 41 (6.4) | 54 (8.4) | 65 (10.1) | 309 (48.2) |
Carrier | 26 | 14 (53.9) | 2 (7.7) | 4 (15.4) | 1 (3.9) | 3 (11.5) | 2 (7.7) | 19 (73.1)* | |
Any | Non-carrier | 436 | 230 (52.8) | 35 (8.0) | 65 (14.9) | 30 (6.9) | 30 (6.9) | 46 (10.6) | 210 (48.2) |
Carrier | 231 | 102 (44.2) | 26 (11.3) | 43 (18.6) | 12 (5.2) | 27 (11.7) | 21 (9.1) | 118 (51.1) |