Skip to main content

Table 3 HFE genotype distribution according to etiology and mortality

From: Hereditary Hemochromatosis (HFE) genotypes in heart failure: Relation to etiology and prognosis

Variant Genotype Distribution IHD (n = 332) Hypertension (n = 61) DCM (n = 108) Valve disease (n = 42) Other (n = 57) Unknown (n = 67) Deceased (n = 328) (%)
C282Y Non-carrier 594 303 (51.0) 51 (8.6) 93 (15.7) 38 (6.4) 49 (8.3) 60 (10.1) 290 (48.8)
  Carrier 73 29 (39.7) 10 (13.7) 15 (20.6) 4 (5.5) 8 (11.0) 7 (9.6) 38 (52.0)
H63D Non-carrier 523 268 (51.2) 46 (8.8) 80 (15.3) 35 (6.7) 39 (7.5) 55 (10.5) 263 (50.3)
  Carrier 144 64 (44.4) 15 (10.4) 28 (19.4) 7 (4.9) 18 (12.5) 12 (8.3) 65 (45.1)
S65C Non-carrier 641 318 (49.6) 59 (9.2) 104 (16.2) 41 (6.4) 54 (8.4) 65 (10.1) 309 (48.2)
  Carrier 26 14 (53.9) 2 (7.7) 4 (15.4) 1 (3.9) 3 (11.5) 2 (7.7) 19 (73.1)*
Any Non-carrier 436 230 (52.8) 35 (8.0) 65 (14.9) 30 (6.9) 30 (6.9) 46 (10.6) 210 (48.2)
  Carrier 231 102 (44.2) 26 (11.3) 43 (18.6) 12 (5.2) 27 (11.7) 21 (9.1) 118 (51.1)
  1. DCM = dilated cardiomyopathy, IHD = ischemic heart disease, Other = HF due to atrial fibrillation or rare diseases, Unknown = no single disease could be assigned as the cause of HF, Deceased = deceased in the follow up period, *p = 0.019