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Table 2 Association between the MCF2L2 genetic polymorphisms and diabetic nephropathy

From: Effects of MCF2L2, ADIPOQ and SOX2 genetic polymorphisms on the development of nephropathy in type 1 Diabetes Mellitus

SNP ID
Hit Orientation
Group Genotype Frequency Allele Frequency Association Significance
P-value/Odds ratio (95% CI)
rs35069869 Women AA AG GG A G  
A/G T1D without DN 174 (0.489) 153 (0.430) 29 (0.081) 0.704 0.211  
  T1D with DN 135 (0.509) 109 (0.411) 21 (0.079) 0.715 0.285 0.661 a
  Men       
  T1D without DN 125 (0.519) 101 (0.419) 15 (0.062) 0.728 0.272  
  T1D with DN 150 (0.479) 137 (0.438) 26 (0.083) 0.698 0.302 0.273 a
rs35368790 Women GG GC CC G C  
G/C T1D without DN 168 (0.471) 151 (0.423) 38 (0.106) 0.682 0.318  
  T1D with DN 134 (0.511) 107 (0.408) 33 (0.105) 0.716 0.284 0.204 a
  Men       
  T1D without DN 107 (0.442) 110 (0.455) 25 (0.103) 0.669 0.331  
  T1D with DN 146 (0.466) 134 (0.428) 33 (0.105) 0.681 0.319 0.696 a
rs7639705 Women TT TG GG T G  
T1165G T1D without DN 213 (0.603) 125 (0.354) 15 (0.043) 0.780 0.220  
Leu359Ile T1D with DN 188 (0.712) 65 (0.246) 11 (0.042) 0.835 0.165 0.017/0.701 (0.524-0.938) a
0.018/0.757 b
  Men       
  T1D without DN 157 (0.651) 73 (0.303) 11 (0.046) 0.803 0.197  
  T1D with DN 183 (0.590) 115 (0.371) 12 (0.039) 0.776 0.224 0.275 a
  1. T1D = type 1 diabetes, DN = diabetic nephropathy. Association significances = a. test for allele frequency difference (additive model), and b. for Armitage's trend.