Table 1 Genotype and allele frequencies of the rs6679677, rs17696736 and rs763361 SNPs in the type 1 diabetes patients and control subjects.
SNP (Gene region) | Cases (%) (N = 154) | Control(%) (N = 230) | Odds ratio (95%CI) | P |
|---|---|---|---|---|
rs6679677 (PHTF1-PTPN22) | ||||
AA | 13(8.4) | 6(2.6) | 4.23(1.56-11.52) | 0.0047 |
AC | 53(34.5) | 52(22.6) | 1.99(1.26-3.16) | 0.0034 |
CC | 88(57.1) | 172(74.8) | 1* | |
A | 79(25.6) | 64(13.9) | 2.13(1.48-3.08) | 0.00001 |
C | 229(74.4) | 396(86.1) | 1* | |
rs17696736 (C12orf30) | ||||
AA | 38(24.7) | 88(38.3) | 1* | |
AG | 83(53.9) | 109(47.4) | 1.76(1.10-2.84) | 0.0194 |
GG | 33(21.4) | 33(14.3) | 2.32(1.25-4.28) | 0.0074 |
A | 159(51.6) | 285(61.9) | 1* | |
G | 149(48.4) | 175(38.1) | 1.53(1.14-2.04) | 0.0046 |
rs763361 (CD226) | ||||
CC | 36(23.4) | 76(33.1) | 1* | |
CT | 79(51.3) | 118(51.3) | 1.41(0.87-2.30) | 0.16 |
TT | 39(25.3) | 36(15.6) | 2.29(1.25-4.18) | 0.0071 |
C | 151(49.1) | 270(58.7) | 1* | |
T | 157(50.9) | 190(41.3) | 1.48(1.11-1.98) | 0.0084 |