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Table 6 Estimated risk for selected demographic characteristic and major risk factors with estrogen receptor-β exon 7, codon 392 in different genotypes

From: Estrogen Receptor-Beta Gene Polymorphism in women with Breast Cancer at the Imam Khomeini Hospital Complex, Iran

Breast cancer Yes No Pvalue OR (95% CI)
Genotype n = 150 n = 147   
Normala 135(47.9%) 147(52.1%) 0.029 1.0(reference)
Heterozygoteb 13(100%) -   -
Homozygotec 2(100%) -   -
Age at menarche (years) </= 12 > 12 P value OR (95% CI)
Genotype n = 60 n = 90   
Normal 50(37.0%) 85(63%) 0.437 1.0(reference)
Heterozygote 9(69.2%) 4(30.8%)   0.261(0.077-0.893)
Homozygote 1(50%) 1(50%)   0.588(0.036 -9.613)
First- degree family history of breast cancer Affected Not affected P value OR (95% CI)
Genotype n = 19 n = 131   
Normal 7(5.2%) 128(94.8%) 0.001 1.0(reference)
Heterozygote 10(76.9%) 3(23.1%)   0.016(0.004- 0.073)
Homozygote 2(100%) -   -
Lymph node metastases Yes No P value OR (95% CI)
Genotype n = 23 n = 127   
Normal 14(10.4%) 121(89.6%) 0.001 1.0(reference)
Heterozygote 7(53.8%) 6(46.2%)   0.099(0.029 - 0.337)
Homozygote 2(100%) -   -
  1. a Genotype normal or 329CC, CTC/CTC, b Genotype heterozygote or 329CG, CTC/CTG, c Genotype homozygote or 329GG, CTG/CTG