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Table 5 Allelic frequencies of estrogen receptor-β exon 7, codon 392 (CTC/CTG) in the study population: breast cancer cases versus control groups and breast cancer cases in the presence versus the absence of major risk factors

From: Estrogen Receptor-Beta Gene Polymorphism in women with Breast Cancer at the Imam Khomeini Hospital Complex, Iran

   ER-β Alleles
Characteristic   Ca Gb
Breast cancer    
Case (n = 150) 283(94.3%) 17(5.7%)
Control (n = 147) 294(100%) -
   χ2 = 17.122, P = 0.001
Age at menarche(years)    
</= 12 (n = 60) 109(90.8%) 11(9.2%)
> 12 (n = 90) 174(96.7%) 6(3.3%)
   χ2 = 4.583, P = 0.032
Age at menopause (years)    
=< 50 (n = 47) 87(92.6%) 7(7.4%)
> 50 (n = 12) 24(100%) -
   χ2 = 1.884, P = 0.17
ABO blood groups    
A (n = 27) 51(94.4%) 3(5.6%)
B (n = 14) 26(92.9%) 2(7.1%)
AB (n = 6) 12(100%) -
O (n = 103) 194(94.2%) 12(5.8%)
   χ2 = 0.058, P = 0.81
Race    
Arab & Armani (n = 3) 6(100%) -
Fars (n = 60) 114(95.0%) 6(5.0%)
Lor & Kurdish (n = 18) 32(88.9%) 4(11.1%)
Turkish (n = 46) 88(95.7%) 4(4.3%)
Gilaki & Mazani (n = 23) 43(93.5%) 3(6.5%)
   χ2 = 0.05, P = 0.822
Family history of breast cancer    
First-degree family affected (n = 19) 24(63.2%) 14(36.8%)
Not affected (n = 131) 259(98.9%) 3(1.1%)
   χ2 = 78.847, P = 0.001
Lymph node metastases    
Yes (n = 23) 35(76.1%) 11(23.9%)
No (n = 127) 248(97.6%) 6(2.4%)
   χ2 = 33.838, P = 0.001
ER expression in breast cancer tissue    
Positive (n = 40) 70(87.5%) 10(12.5%)
Negative (n = 92) 179(97.3%) 5(2.7%)
Not studied (n = 18) 34(94.4%) 2(5.6%)
   χ2 = 5.161, P = 0.023
  1. a Allele 392C, CTC, b Allele 392G, CTG