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Table 4 Genotypic distribution frequencies of codon 392 in exon 7 of estrogen receptor-β gene and selected demographic characteristics and major risk factors

From: Estrogen Receptor-Beta Gene Polymorphism in women with Breast Cancer at the Imam Khomeini Hospital Complex, Iran

Characteristic 002 % 01b% 11c % Test result
BMI (kg/m 2 )     
</= 18.5 80.0 20.0 - χ2 = 0.144
P = 0.705
18.5-24.9 91.2 7.0 1.8  
25-29.9 90.9 9.1 -  
> 30 87.9 9.1 3.0  
Total 90.0 8.7 1.3  
Onset age of breast cancer (years)     
</= 40 91.7 8.3 - χ2 = 0.959
P = 0.328
> 40 89.2 8.8 2.0  
Total 90.0 8.7 1.3  
Family history of breast cancer     
First-degree family affected 36.8 52.6 10.5 χ2 = 27.645
P = 0.001
Not affected 97.7 2.3 -  
Total 90 8.7 1.3  
Lymph node metastases     
Yes 60.9 30.4 8.7 χ2 = 17.314
P = 0.001
No 95.3 4.7 -  
Total 90.0 8.7 1.3  
ER expression in breast cancer tissue     
Positive 80.0 15.0 5.0 χ2 = 4.799
P = 0.028
Negative 94.6 5.4 -  
Not studied 88.9 11.1 -  
Total 90.0 8.7 1.3  
  1. a Genotype normal or 329CC, CTC/CTC, b Genotype heterozygote or 329CG, CTC/CTG, c Genotype homozygote or 329GG, CTG/CTG