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Table 1 Allele and genotype frequencies of frequent polymorphisms in NOS1AP*

From: Mutation screening of NOS1AP gene in a large sample of psychiatric patients and controls

Polymorphisms#

Location

Number of alleles (frequency)

Number of Genotype (frequency)

  

Allele 1

Allele 2

P (df = 1)

11

12

22

P (df = 2)

rs10918776

Intron 2

G

C

     

   SCZ

 

100 (0.77)

32 (0.23)

0.46

42

22

5

0.57§

   ASD

 

117 (0.72)

45 (0.28)

0.06

39

37

4

0.06§

   Controls

 

142 (0.80)

34 (0.20)

 

57

28

3

 

rs10800405

Intron 3

C

G

     

   SCZ

 

91 (0.76)

31 (024)

0.92

37

25

3

0.98§

   ASD

 

102 (0.74)

36 (0.26)

0.63

34

33

1

0.60§

   Controls

 

113 (0.77)

35 (0.23)

 

43

29

3

 

rs347306 and rs347307

Intron 5

C and T

T and C

     

   SCZ

 

74 (0.56)

60 (0.44)

0.19

20

38

12

0.23

   ASD

 

82 (0.52)

76 (0.48)

0.98

17

41

20

0.46

   Controls

 

87 (0.52)

81 (0.48)

 

15

54

18

 

rs3751285

Intron 6

A

G

     

   SCZ

 

68 (0.77)

20 (0.33)

0.35

28

12

4

0.32§

   ASD

 

97 (0.71)

39 (0.29)

0.96

34

27

6

0.97

   Controls

 

106 (0.72)

42 (0.28)

 

39

31

6

 

rs3751284

Exon 6

C

T

     

   SCZ

 

58 (0.66)

30 (0.34)

0.35

20

18

6

0.45

   ASD

 

75 (0.55)

61 (0.45)

0.32

20

34

13

0.69

   Controls

 

88 (0.60)

60 (0.40)

 

26

39

11

 

rs905721

Intron 8

C

T

     

   SCZ

 

96 (0.70)

42 (0.30)

0.10

33

30

6

0.22

All SCZ

 

353 (0.62)

213 (0.38)

0.92

114

125

44

0.86

   ASD

 

104 (0.66)

54 (0.34)

0.33

31

41

6

0.02

All ASD

 

360 (0.64)

198 (0.36)

0.41

115

130

34

0.27

   Controls

 

98 (0.65)

52 (0.35)

 

37

24

14

 

All controls

 

309 (0.62)

189 (0.38)

 

102

105

42

 

rs348624 and rs1964052

Exon 9 and intron 9

C and C

T and T

     

   SCZ

 

121 (0.89)

15 (0.11)

0.48

54

13

1

0.49§

All SCZ

 

500 (0.87)

74 (0.13)

0.34

218

63

6

0.50

   ASD

 

132 (0.85)

24 (0.15)

0.07

55

18

3

0.07§

All ASD

 

472 (0.86)

74 (0.14)

0.22

206

60

7

0.39

   Controls

 

137 (0.91)

13 (0.09)

 

62

13

0

 

All controls

 

283 (0.89)

34 (0.11)

 

128

29

2

 

rs164146 and rs164147

Exon 10

G and C

C and A

     

   SCZ

 

104 (0.83)

22 (0.17)

0.71

43

18

2

0.73§

   ASD

 

133 (0.84)

25 (0.16)

0.99

56

20

2

0.91§

   Controls

 

128 (0.84)

24 (0.16)

 

57

23

1

 
  1. *Polymorphisms included have a minor allele frequency above 0.05. # Markers are listed from centromere au telomere. § Fischer exact Test. Significant P values (<0.05) are in bold. Abbreviations: ASD: autism spectrum disorders, SCZ: schizophrenia.