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Table 2 Results of logistic regression analysis

From: CXCR1 and SLC11A1polymorphisms affect susceptibility to cutaneous leishmaniasis in Brazil: a case-control and family-based study

Gene/Marker

Groups Compared

Allele

OR

95% CI

Global Pvalue

CXCR2_rs4674259

CL vs DTH

C vs T

1.03

0.60-1.76

0.908

 

CL vs NC

C vs T

0.91

0.53-1.58

0.752

 

ML vs DTH

C vs T

1.92

1.05-3.51

0.028

 

ML vs NC

C vs T

1.71

0.93-3.14

0.076

 

CL vs DTH+NC

C vs T

0.97

0.60-1.56

0.909

 

ML vs DTH+NC

C vs T

1.82

1.07-3.07

0.023

 

CL+ML vs DTH+NC

C vs T

1.26

0.85-1.88

0.239

CXCR1_rs2854386

CL vs DTH

C vs G

2.31

1.07-4.96

0.027

 

CL vs NC

C vs G

2.48

1.21-5.10

0.009

 

ML vs DTH

C vs G

1.55

0.72-3.35

0.254

 

ML vs NC

C vs G

1.72

0.84-3.54

0.127

 

CL vs DTH+NC

C vs G

2.38

1.23-4.57

0.006

 

ML vs DTH+NC

C vs G

1.63

0.84-3.14

0.132

 

CL+ML vs DTH+NC

C vs G

2.01

1.19-3.40

0.007

CXCR1_rs2234671

CL vs DTH

C vs G

2.06

0.93-4.56

0.069

 

CL vs NC

C vs G

1.91

0.89-4.10

0.087

 

ML vs DTH

C vs G

1.73

0.74-4.01

0.190

 

ML vs NC

C vs G

1.62

0.72-3.63

0.226

 

CL vs DTH+NC

C vs G

1.96

0.98-3.89

0.044

 

ML vs DTH+NC

C vs G

1.66

0.79-3.46

0.160

 

CL+ML vs DTH+NC

C vs G

1.84

1.04-3.23

0.030

SLC11A1_rs 17235416

CL vs DTH

DEL vs IN

1.35

0.63-2.87

0.428

 

CL vs NC

DEL vs IN

0.87

0.42-1.79

0.714

 

ML vs DTH

DEL vs IN

1.10

0.53-2.30

0.781

 

ML vs NC

DEL vs IN

0.73

0.35-1.48

0.383

 

CL vs DTH+NC

DEL vs IN

1.07

0.57-1.99

0.820

 

ML vs DTH+NC

DEL vs IN

0.88

0.47-1.66

0.709

 

CL+ML vs DTH+NC

DEL vs IN

0.97

0.58-1.62

0.929

  1. Under an additive model for case-control comparisons of CL, ML and L. braziliensis per se (CL+ML) disease groups with NC, DTH+ or NC+DTH+ control groups. Only the data for markers where significant associations (P = 0.05; bold) were observed in this or the family-based (Table 3) analysis are shown. OR = odds ratio; CI = 95% confidence interval.