CXCR1 and SLC11A1polymorphisms affect susceptibility to cutaneous leishmaniasis in Brazil: a case-control and family-based study

Table 1 Information on the polymorphic markers genotyped for CXCR1, CXCR2 and SLC11A1.

Gene/Marker	Physical Position (bp)	Alleles¹	MAF	Caucasian	Asian	African
CXCR2_rs4674259 (5' UTR)	218699250	T>C	0.388	0.517	0.341	0.883
CXCR1_rs2854386 3' region	218735747	C>G	0.218	0.058	0.100	0.425
CXCR1_rs2234671 Exon 1 S276T	218737353	C>G	0.194	0.058	0.100	0.317
CXCR1_rs3138060 Intron 1	218739745	G>C	0.142	0.058	0.102	0.129
SLC11A1_rs7573065 (-237 bp 5' UTR)	218954951	C>T	0.090³	-	-	0⁴
SLC11A1_rs2276631 (274²; exon 3, Phe66Phe)	218957257	C>T	0.289	0.224	0.102	0.127
SLC11A1_rs3731865 (469+14G/C²; intron 4)	218958247	G>C	0.227	0.27²	0.08²	0.120⁴
SLC11A1_rs17221959 (823²; exon 8, Gly249Gly)	218960874	C>T	0.266	0.02²	0.15²	0.310⁴
SLC11A1_rs2279015 (1465-85G/A²; intron 13)	218967514	C>T	0.379	0.342	0.307	0.942
SLC11A1_rs17235409 (1703²; exon 15, D543N)	218967976	G>A	0.089³	0.01²	0.18²	0.120⁴
SLC11A1_ rs17235416 (1729+55del4²; 3' UTR TGTG IN/DEL)	218968058	IN/DEL	0.176	0.01²	0.18²	0.188⁴

Physical positions of markers are given according to Build 36.3 of the human genome. Where available, allele frequencies for the minor allele (MAF) in Brazil are shown for Caucasian, Asian and African populations (Hapmap CEU, JPT and YRI unless otherwise referenced). ¹ Major>minor alleles for this Brazilian population; ²[21], bp positions of variants relative to an arbitrary site 76 bp upstream of the methionine start codon; ³Allele frequency too low to be taken forward in the association analyses; ⁴[31].

ISSN: 1471-2350