No association of the polymorphisms of the frizzled-related protein gene with peak bone mineral density in Chinese nuclear families

Table 5 P values of QTDT analyses for FRZB gene and BMD in male-offspring nuclear families

	rs6433993	rs409238	rs288324	rs4666865
Tests of population stratification
Lumbar spine BMD	0.5236	0.7656	0.6731	0.8238
Total hip BMD	0.7361	0.6912	0.9392	0.8309
Femoral neck BMD	0.8698	0.7332	0.8995	1.0000
Test of total association
Lumbar spine BMD	0.5978	0.2937	0.2672	0.0299
Total hip BMD	0.5233	0.6343	0.7110	0.1164
Femoral neck BMD	0.8093	0.8872	0.7740	0.2963
Test of within-family association
Lumbar spine BMD	0.4155	0.4277	0.3610	0.3712
Total hip BMD	0.9793	0.9271	0.8014	0.5332
Femoral neck BMD	0.9752	0.7143	0.8034	0.6109
p 1000 permutations of within-family association
Lumbar spine BMD	0.3860	0.3700	0.3680	0.2780
Total hip BMD	0.9740	0.7350	0.8280	0.6520
Femoral neck BMD	0.9800	0.9290	0.8310	0.5290

BMD values are adjusted for age, height and weight. Bold indicates significant p values (p < 0.05)

ISSN: 1471-2350