Table 5 Recessive model study-specific and meta-analysis results
From: Genomewide association study for onset age in Parkinson disease
| Â | GenePD-PROGENI | Mayo-Perlegen LEAPS | GWAS Meta-analysis | Milan, Italian | Three Sample Meta-analysis | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
SNP | effect | p-value | effect | p-value | Direction of Effect | effect | p-value | effect | p-value | Direction of Effect | effect | p-value |
rs10767971 | 4.23 | 9.3 × 10-6 | 2.35 | 1.3 × 10-1 | ++ | 3.71 | 4.3 × 10-6 | 2.40 | 2.6 × 10-2 | +++ | 3.24 | 5.4 × 10-7 |
rs7577851 | -8.64 | 1.2 × 10-4 | -8.03 | 3.1 × 10-2 | -- | -8.48 | 9.8 × 10-6 | -3.89 | 1.3 × 10-1 | --- | -6.85 | 8.7 × 10-6 |
rs1355637 | -5.10 | 2.3 × 10-3 | -14.25 | 4.1 × 10-5 | -- | -6.83 | 5.1 × 10-6 | 1.10 | 6.0 × 10-1 | --+ | -4.19 | 6.2 × 10-4 |
rs11899121 | -3.41 | 8.0 × 10-5 | -3.33 | 1.6 × 10-2 | -- | -3.39 | 3.5 × 10-6 | 0.43 | 6.5 × 10-1 | --+ | -1.99 | 6.3 × 10-4 |
rs12829697 | -10.51 | 8.5 × 10-5 | -10.33 | 3.0 × 10-2 | -- | -10.47 | 7.0 × 10-6 | 0.68 | 8.1 × 10-1 | --+ | -6.15 | 7.2 × 10-4 |
rs17663983 | -16.72 | 1.2 × 10-5 | -25.53 | 4.6 × 10-1 | -- | -16.83 | 8.1 × 10-6 | 5.77 | 2.9 × 10-1 | --+ | -9.46 | 2.3 × 10-3 |
rs12261736 | -8.48 | 1.9 × 10-6 | -0.56 | 8.9 × 10-1 | -- | -7.14 | 9.6 × 10-6 | -0.73 | 4.9 × 10-1 | --- | -2.65 | 2.7 × 10-3 |
rs1420143 | 3.31 | 7.9 × 10-4 | 6.05 | 1.3 × 10-3 | ++ | 3.90 | 7.3 × 10-6 | -0.52 | 5.9 × 10-1 | ++- | 1.89 | 3.3 × 10-3 |
rs676495 | -6.90 | 1.9 × 10-5 | -11.27 | 2.4 × 10-1 | -- | -7.02 | 9.1 × 10-6 | 1.86 | 2.7 × 10-1 | --+ | -2.84 | 1.4 × 10-2 |
rs7556447 | -13.34 | 2.1 × 10-5 | -11.11 | 1.9 × 10-1 | -- | -13.08 | 7.9 × 10-6 | -0.44 | 7.7 × 10-1 | --- | -3.01 | 2.3 × 10-2 |
rs4791571 | -5.18 | 1.3 × 10-5 | -6.39 | 2.4 × 10-1 | -- | -5.23 | 5.9 × 10-6 | 2.57 | 3.5 × 10-2 | --+ | -1.52 | 6.9 × 10-2 |