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Table 4 Dominant model study-specific and meta-analysis results

From: Genomewide association study for onset age in Parkinson disease

 

GenePD-PROGENI

Mayo-Perlegen LEAPS

GWAS Meta-analysis

Milan, Italian

Three Sample Meta-analysis

SNP

effect

p-value

effect

p-value

Direction of Effect

effect

p-value

effect

p-value

Direction of Effect

effect

p-value

rs17565841

-5.08

4.7 × 10-6

-3.68

2.0 × 10-1

--

-4.90

1.9 × 10-6

-1.94

3.6 × 10-2

---

-3.26

2.1 × 10-6

rs1941184

-2.94

1.3 × 10-4

-2.94

1.0 × 10-2

--

-2.94

3.7 × 10-6

-1.25

1.2 × 10-1

---

-2.28

4.3 × 10-6

rs10918270

-3.26

2.9 × 10-5

-2.74

1.5 × 10-2

--

-3.09

1.2 × 10-6

-0.87

2.9 × 10-1

---

-2.26

7.5 × 10-6

rs3887942

4.17

7.2 × 10-4

7.10

1.5 × 10-3

++

4.85

6.4 × 10-6

0.93

2.6 × 10-1

+++

2.37

2.7 × 10-4

rs12261736

-4.03

9.5 × 10-6

-2.04

2.8 × 10-1

--

-3.66

7.3 × 10-6

-0.46

5.7 × 10-1

---

-2.07

3.5 × 10-4

rs10773917

3.15

3.8 × 10-5

2.58

3.5 × 10-2

++

2.99

3.7 × 10-6

-0.13

8.7 × 10-1

++-

1.75

4.8 × 10-4

rs10420134

-3.21

5.8 × 10-5

-3.12

5.1 × 10-2

--

-3.19

7.1 × 10-6

0.56

5.1 × 10-1

--+

-1.67

2.3 × 10-3

rs9904572

3.57

4.3 × 10-6

2.72

6.4 × 10-2

++

3.38

7.2 × 10-7

-1.05

1.9 × 10-1

++-

1.55

3.1 × 10-3

rs17817190

-3.87

3.9 × 10-5

-5.27

2.1 × 10-2

--

-4.07

2.5 × 10-6

1.30

2.1 × 10-1

--+

-1.85

5.3 × 10-3

rs1572662

3.57

4.1 × 10-5

4.89

7.5 × 10-2

++

3.69

7.8 × 10-6

-0.67

4.1 × 10-1

++-

1.45

1.2 × 10-2

rs7076519

-3.73

1.2 × 10-5

-3.81

3.0 × 10-2

--

-3.74

9.3 × 10-7

1.48

6.2 × 10-2

--+

-1.23

2.6 × 10-2