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Table 2 Association analyses of INSIG2 rs7566605 with BMI

From: Association analyses of the INSIG2polymorphism in the obesity and cholesterol levels of Korean populations

   

n (mean ± SD)

Population

Group

MAF

G/G

G/C

C/C

Kirin

Total

0.35

428(26.5 ± 4.61)

432(26.3 ± 4.74)

131(26.1 ± 4.88)

   

P ANOVA = 0.689, P dom = 0.423, P rec = 0.564

 

Female

0.35

400(26.1 ± 4.41)

400(25.7 ± 3.96)

120(25.8 ± 4.82)

   

P ANOVA = 0.311, P dom = 0.137, P rec = 0.864

 

Male

0.38

28(32.0 ± 3.98)

32(34.2 ± 6.36)

11(29.7 ± 4.79)

   

P ANOVA = 0.040, P dom = 0. 405, P rec = 0.0525

Yeungnam

Total

0.35

312(27.0 ± 3.35)

329(27.2 ± 3.57)

93(27.0 ± 3.26)

   

P ANOVA = 0.824, P dom = 0.751, P rec = 0.789

 

Female

0.34

121(26.1 ± 3.80)

119(26.8 ± 4.06)

34(26.3 ± 3.92)

   

P ANOVA = 0.378, P dom = 0.218, P rec = 0.837

 

Male

0.36

191(27.5 ± 2.93)

210(27.3 ± 3.26)

59(27.3 ± 2.78)

   

P ANOVA = 0.765, P dom = 0.464, P rec = 0.835

Multicenter

Total

0.33

272(23.1 ± 3.31)

287(22.7 ± 2.99)

66(23.5 ± 3.24)

   

P ANOVA = 0.161, P dom = 0.461, P rec = 0.145

 

Female

0.35

168(22.9 ± 3.41)

183(22.3 ± 3.03)

47(23.4 ± 3.29)

   

P ANOVA = 0.066, P dom = 0.234, P rec = 0.127

 

Male

0.31

104(23.2 ± 3.15)

104(23.4 ± 2.81)

19(23.7 ± 3.18)

   

P ANOVA = 0.790, P dom = 0.581, P rec = 0.585

  1. The P values for BMI in subjects with minor alleles were assessed by an ANOVA for a difference among three genotypes or by a T-test for the dominant and recessive models. The significant threshold was 0.0015 for the Kirin population (11 phenotypes and 3 different models) and 0.0033 for the Yeungnam and Multicenter populations (5 phenotypes and 3 different models).
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BMC Medical Genetics

ISSN: 1471-2350

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