Table 3 Haplotype distributions of DRD2 in populations 1 and 2 using the UNPHASED software.
From: Two-stage case-control association study of dopamine-related genes and migraine
DRD2 | ||||||
|---|---|---|---|---|---|---|
Population 1 Overall P-value = 0.00276 | Population 2 Overall P-value = 0.048 | |||||
MarkeraHaplotype | Cases (%) | Controls (%) | Haplotype-specific P; OR (CI) | Cases (%) | Controls (%) | Haplotype-specific P |
6 7 8 9 10 | ||||||
C C G C G | 49 (9.9) | 58 (11.5) | 0.423 | 66 (13.9) | 47 (9.1) | 0.018 |
C C G C C | 47 (10.1) | 40 (7.9) | 0.233 | 42 (8.8) | 55 (10.7) | 0.331 |
C A A C C | 40 (8.6) | 76 (15.1) | 0.00199; 1.88 (1.25-2.82) c | 53 (11.1) | 53 (10.3) | 0.660 |
T C G C G | 44 (9.4) | 27 (5.4) | 0.0139; 1.85 (1.13-3.04) | 37 (7.8) | 28 (5.4) | 0.136 |
T C A T C | 287 (62.0) | 303 (60.1) | 0.581 | 278 (58.4) | 333 (64.5) | 0.047 |
TH | ||||||
Population 1 Overall P-value = 0.0283 | Population 2 Overall P-value = 0.2 | |||||
Marker b Haplotype | Cases (%) | Controls (%) | Haplotype-specific P; OR (CI) | Cases (%) | Controls (%) | Haplotype-specific P |
1 2 | ||||||
A C | 82 (17.4) | 68 (13.5) | 0.0370; 1.34 (0.94-1.90) | 100 (20.9) | 86 (15.7) | 0.129 |
A T | 108 (23.0) | 118 (23.7) | 0.674 | 82 (17.2) | 123 (22.4) | 0.141 |
G C | 162 (34.6) | 149 (29.9) | 0.127 | 147 (30.8) | 178 (32.5) | 0.935 |
G T | 118 (25.0) | 165 (32.9) | 0.00573; 1.47 (1.11-1.94) c | 149 (31.1) | 161 (29.4) | 0.953 |