Two-stage case-control association study of dopamine-related genes and migraine

BMC Medical Genetics

Table 2 Haplotype analysis of DRD2 and TH SNPs in 263 migraine patients and 274 unrelated non-migraine controls using the UNPHASED software.

Gene	Marker^aHaplotype	Global P	Best Haplotype-P (Adjusted P-Value)	Risk Haplotype-OR
*DRD2*	6 7	0.00519	0.00178 (0.00450)	1.37 (1.05-1.79)
	6 7 8	0.00175	9.74e-04 (0.00400)	1.74 (1.08-2.80)
	6 7 8 10	0.00135	0.00100 (0.00460)	1.84 (1.12-3.02)
	6 7 8 9 10^b	0.00276	0.00199 (0.00889)	1.85 (1.13-3.04)
TH	1 2	0.0283	0.00573 (0.0150)	1.34 (0.94-1.90)

^a DRD2: 6- rs12363125; 7- rs2283265; 8- rs2242592; 9- rs1554929; 10- rs2234689; TH: 1- rs6356; 2-rs2070762.
^bBest allelic combination (higher OR)

ISSN: 1471-2350