Figure 6

Meiotic crossovers in multiplex autism families. Analysis of chromosome 9 showing two probands with autism having shared alleles that are not inherited by unaffected siblings. We used pediSNP to analyze genotype data from a family with two parents (father Fa, mother Mo) and four daughters (probands D1 and D4, unaffected siblings D2 and D3). The top four panels (1-4) show the conventional SNPtrio output for the four father/mother/daughter trios. Panels 5-10 show the reverse trios of each pair of daughters relative to the father. The bottom six panels (11-16) show the reverse trios of daughters relative to the mother. The yellow box at 9p indicates a region where the two affected daughters had inherited identical alleles from both parents (red ovals) and those two alleles were the opposite alleles inherited by the unaffected daughters. Throughout the genome in multiplex families, such regions are relatively rare. For this families, only two such regions were found: 9p24 (shown in this figure), and part of 16p13.3.