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Figure 2 | BMC Medical Genetics

Figure 2

From: Locations and patterns of meiotic recombination in two-generation pedigrees

Figure 2

Meiotic recombination in pedigrees with three children. Identification of meiotic recombination events in two-generation pedigrees having two parents and three children. Seventeen meiotic recombination events were identified via pediSNP on chromosome 2 for three children of Autism Genetic Resource Exchange (AGRE) family AU1098. The top three panels correspond to conventional trios consisting of Father/Mother/Son2, Father/Mother/Son3 and Father/Mother/Daughter1. They contained the expected preponderance of BPI signals. The following six panels are "reverse" pedigrees for all three combinations of the two children versus father (panels 4-6) and versus the mother (panels 7-9). A vertical pink line with arrows identifies a meiotic recombination site of Daughter1, on a parent-specific allele, as indicated by the panel's label of father (middle three tracks) or mother (bottom three tracks). Lime colored lines denote crossovers in Son2 and blue colored lines denote Son3. The child who had a recombination event can be identified by the common individual (Child1 or Child2 of two separate Child/Child/Parent panels) of that event. For example, the Son2/Son3/Father trio ("Rev_Son2.Son3___Fa''; panel 4) and Son3/Daughter1/Father ("Rev_Son3.Dau1___Fa'' (panel 6) indicate that three separate crossover events occurred on Son3's paternal gamete (see three blue arrows in panels 4 and 6). In each of these three cases, an arrow points to the edge of a red track 2 box in two separate panels.

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