Table 3 Penetrence, relative risk and odds ratio of the two-locus combinations.
Two-locus combination | SNP1 and SNP2 | SNP1 and SNP3 | |
|---|---|---|---|
Penetrance | Unadjusted |
Pen( |
Pen( |
| Â | Â |
Pen( |
Pen( |
| Â | Â | Â |
Pen( |
| Â | Adjusted |
Pen( |
Pen( |
| Â | Â |
Pen( |
Pen( |
| Â | Â | Â |
Pen( |
R and 95% CI | Unadjusted | 3.70, (2.85, 4.85) | 2.55, (2.10, 3.15) |
| Â | Adjusted | 3.40, (2.40, 4.60) | 2.35, (1.85, 2.95) |
ORH and 95% CI | Unadjusted | 3.70, (2.85, 4.85) | 3.37, (2.66, 4.34) |
| Â | Adjusted | 3.40, (2.40, 4.60) | 3.05, (2.27, 4.01) |
ORL and 95% CI | Unadjusted | 0.27, (0.21,0.35) | 0.31, (0.23, 0.40) |
| Â | Adjusted | 0.29, (0.22, 0.42) | 0.34, (0.25, 0.47) |
SS and 95% CI | Unadjusted | 680, (480, 1040) | 680, (460, 1040) |
| Â | Adjusted | 800, (500, 1500) | 810, (520, 1520) |
) = 0.48F,
) = 0.40F;
) = 1.78F.
) = 1.02F;
) = 2.60F.- Note: There were two genotype combinations for SNP1 and SNP2,
= {TTAA, TCAA, CCAA, TTAG, TTGG} and 
= {TCAG, CCAG, TCGG, CCGG}, three genotype combinations for SNP1 and SNP3, 
= {TTCC}, 
= {TCCC, CCCC, TTCA, TTAA} and 
= {TCCA, CCCA, TCAA, CCAA}. Pen(G) denotes the penetrance of G. R: relative risk. For SNP 1 and SNP2, R = pen()/pen() = α/β; for SNP1 and SNP3, R = pen()/pen() = pen()/pen() = θ. ORH (ORL): the odds ratio of the high-risk (low-risk) genotype group. SS: the sample size required to reach 80% power. Adjusted (Unadjusted): based on the penetrance estimated using the method proposed in this article (the traditional method). F is the prevalence and F = 10-4.