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Table 3 Association of PCK1 variants with type 2 diabetes among UK-resident South Asians

From: The promoter polymorphism -232C/G of the PCK1 gene is associated with type 2 diabetes in a UK-resident South Asian population

SNP

Gene Region

Allele

Diabetic subjects Fa

Control subjects Fa

Genotype

Diabetic subjects n (%)b

Control subjects n (%)b

Allelic ORc (95% CI)

rs2071023

Promoter

C

0.53

0.57

CC

243 (0.27)

158 (0.34)

1.21

     

CG

447 (0.51)

225 (0.48)

(1.03 - 1.42)

  

G

0.47

0.43

GG

195 (0.22)

88 (0.19)

p = 0.019

rs6070157

Exon 3

C

0.81

0.79

CC

597 (0.67)

305 (0.65)

0.90

     

CT

258 (0.29)

135 (0.29)

(0.74 - 1.08)

  

T

0.19

0.21

TT

38 (0.04)

29 (0.06)

p = 0.257

rs2070756

Exon 7

C

0.72

0.71

CC

456 (0.52)

246 (0.53)

1.00

     

CT

354 (0.40)

171 (0.37)

(0.84 - 1.18)

  

T

0.28

0.29

TT

75 (0.08)

47 (0.10)

p = 0.965

rs2179706

Intron 8

C

0.58

0.56

CC

298 (0.34)

156 (0.34)

0.92

     

CT

424 (0.48)

206 (0.45)

(0.79 - 1.08)

  

T

0.42

0.44

TT

156 (0.18)

100 (0.22)

p = 0.323

rs1042531

3'UTR

T

0.66

0.68

TT

391 (0.44)

206 (0.45)

1.06

     

GT

384 (0.44)

212 (0.46)

(0.89 - 1.25)

  

G

0.34

0.32

GG

104 (0.12)

44 (0.10)

p = 0.528

  1. aF = Allele frequency. bGenotype frequency expressed as number of individuals, n - values in parentheses indicate percentage. cOR = odds ratio, 95% CI = 95% confidence interval. Allelic OR refers to the risk associated with a single copy of the risk allele. All values were calculated using the full dataset, the minimum age of control subjects being 35 years.