Figure 1From: New mutations in the PKD1 gene in Czech population with autosomal dominant polycystic kidney disease The segregation of the PKD1 germline mutation p.E3918X with the disease in family 256. a. Denaturing Gradient Gel Electrophoresis of PCR products of part A of exon 43 of the family 256. Lane 1 represents control. Lanes 2, 3 and 5 represent heterozygous affected members of the family. Lanes 4 and 6 represent healthy members of the family. b. Sequencing pattern of part of the exon 43 (forward) in proband of the family 256 with heterozygous substitution G>T at nucleotide position 11752 of the PKD1 gene (p.E3918X) and control.Back to article page