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Table 3 Associations of NR4A3 SNPs rs1526267, rs12686676 and rs10819699 with anthropometric and metabolic data (TÜF/TULIP cohort, N = 1495)

From: Common polymorphisms within the NR4A3 locus, encoding the orphan nuclear receptor Nor-1, are associated with enhanced β-cell function in non-diabetic subjects

SNP

rs1526267

   

Genotype

GG

GA

AA

p1

p2

p3

N

832

561

102

-

-

-

Age (y)

39 ± 13

39 ± 13

38 ± 14

0.9

0.9

-

BMI (kg/m2)

28.0 ± 7.2

29.4 ± 8.9

28.5 ± 8.4

0.0234

0.0225

-

Body Fat (%)

30.5 ± 10

31.0 ± 11

29.8 ± 10

0.7

0.5

-

Fasting glucose (mM)

5.09 ± 0.54

5.11 ± 0.56

5.07 ± 0.55

0.8

0.9

-

Glucose, 120 min OGTT (mM)

6.25 ± 1.65

6.26 ± 1.68

6.01 ± 1.56

0.4

0.3

-

Insulin sensitivity (HOMA), OGTT (AU)

2.28 ± 2.02

2.61 ± 2.34

2.50 ± 2.08

0.0186

0.17

-

Insulin sensitivity, clamp (U)*

0.090 ± 0.059

0.079 ± 0.047

0.085 ± 0.054

0.0549

0.0274

-

AUCC-peptide-to-AUCGluc ratio, OGTT (·10-9)

310 ± 100

329 ± 114

331 ± 115

0.0054

0.0241

0.07

AUCIns30-to-AUCGluc30 ratio, OGTT (·10-9)

38.3 ± 28

43.3 ± 33

42.5 ± 31

0.0055

0.08

0.3

Insulin, 30 min OGTT (pM)

393 ± 266

501 ± 373

459 ± 372

0.0020

0.0443

0.13

SNP

rs12686676

   

Genotype

GG

GA

AA

p1

p2

p3

N

424

754

317

-

-

-

Age (y)

38 ± 13

39 ± 13

39 ± 13

0.3

0.2

-

BMI (kg/m2)

28.0 ± 7.7

28.8 ± 8.0

28.7 ± 8.2

0.1

0.2

-

Body Fat (%)

30.0 ± 11

31.1 ± 10

30.4 ± 11

0.1

0.3

-

Fasting glucose (mM)

5.09 ± 0.54

5.11 ± 0.56

5.07 ± 0.55

0.7

0.6

-

Glucose, 120 min OGTT (mM)

6.23 ± 1.66

6.32 ± 1.63

6.06 ± 1.70

0.0335

0.06

-

Insulin sensitivity (HOMA), OGTT (AU)

2.28 ± 1.97

2.53 ± 2.32

2.35 ± 1.95

0.14

0.24

-

Insulin sensitivity, clamp (U)*

0.091 ± 0.065

0.083 ± 0.050

0.085 ± 0.050

0.7

0.4

-

AUCC-peptide-to-AUCGluc ratio, OGTT (·10-9)

306 ± 107

325 ± 107

320 ± 105

0.0055

0.0142

0.028

AUCIns30-to-AUCGluc30 ratio, OGTT (·10-9)

37.9 ± 29

41.7 ± 31

40.9 ± 29

0.0041

0.010

0.020

Insulin, 30 min OGTT (pM)

388 ± 301

445 ± 309

478 ± 357

0.0017

0.0058

0.012

SNP

rs10819699

   

Genotype

GG

GA

AA

p1

p2

p3

N

698

637

158

-

-

-

Age (y)

39 ± 13

39 ± 13

38 ± 14

0.5

0.5

-

BMI (kg/m2)

28.3 ± 7.6

28.8 ± 8.1

29.0 ± 8.9

0.4

0.5

-

Body Fat (%)

30.4 ± 10

31.1 ± 10

29.8 ± 11

0.3

0.7

-

Fasting glucose (mM)

5.09 ± 0.55

5.10 ± 0.55

5.09 ± 0.56

1.0

0.9

-

Glucose, 120 min OGTT (mM)

6.23 ± 1.63

6.29 ± 1.67

6.08 ± 1.68

0.3

0.5

-

Insulin sensitivity (HOMA), OGTT (AU)

2.38 ± 2.27

2.48 ± 2.08

2.39 ± 1.91

0.68

0.24

-

Insulin sensitivity, clamp (U)*

0.087 ± 0.058

0.084 ± 0.053

0.087 ± 0.050

0.8

0.2

-

AUCC-peptide-to-AUCGluc ratio, OGTT (·10-9)

313 ± 105

324 ± 110

325 ± 103

0.07

0.1

0.2

AUCIns30-to-AUCGluc30 ratio, OGTT (·10-9)

38.9 ± 30

41.9 ± 31

41.3 ± 29

0.0349

0.0538

0.18

Insulin, 30 min OGTT (pM)

396 ± 288

471 ± 339

372 ± 352

0.0125

0.0201

0.08

  1. Data are given as means ± SD. For statistical analysis, data were log-transformed. p 1 – non-adjusted additive model; p 2 – adjusted additive model: age was adjusted for gender; BMI and body fat were adjusted for gender and age; glucose (Gluc) levels as well as insulin sensitivity (HOMA model, clamp) and insulin (Ins) secretion (AUCC-peptide-to-AUCGluc ratio, AUCIns30-to-AUCGluc30 ratio, plasma insulin at 30 min OGTT) were adjusted for gender, age, and BMI; p 3 – Ins secretion parameters with adjustment for age, BMI, gender and insulin sensitivity. *clamped subgroup (N = 506). AUC – area under the curve; BMI – body mass index; OGTT – oral glucose tolerance test; SNP – single nucleotide polymorphism.
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BMC Medical Genetics

ISSN: 1471-2350

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