Figure 4
From: A mutation in CTSK gene in an autosomal recessive pycnodysostosis family of Pakistani origin
Alignment of conserved motif from the mature region of several members of the papain family of cysteine proteases and various species. The fourteen-residue motif from four human cysteine cathepsins (cathepsin K, cathepsin L, cathepsin S and cathepsin H) and cathepsin K of various species are aligned. The site of the cathepsin K A277V mutation is indicated by the arrow. * indicates highly conserved amino acids while. and: indicate polar → polar and polar → non polar amino acid change, respectively.