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Table 1 Clinical manifestations

From: Mutations in STK11gene in Czech Peutz-Jeghers patients

Family

Case no

Sex

Age at onset/admission

Initial symptoms/signs

Histology of polyps

Location

Cancer

Mutation

A

*A-1

F

10

pigmentation

hamartomatous

throughout GIT

lung, stomach

+

 

A-2

F

2

pigmentation

NA

NA

No

+

B

*B-1

F

36

pigmentation

hamartomatous

throughout GIT

No

+

 

*B-2

M

10

pigmentation

hamartomatous

throughout GIT

No

+

 

*B-3

M

6

pigmentation

hamartomatous

throughout GIT

No

+

C

C-1

F

2

pigmentation

adenomatous

small intestine

No

+

D

D-2

M

50

pigmentation

hyperplastic

colon

No

-

E

E-3

M

10

pigmentation

no polyps

no polyps

No

-

  1. NA – not analysed, GIT – gastrointestinal tract, * – fulfillment of PJS criteria