Table 2 Frequency of the TIRAP-S180L variant in different populations
No. of individuals with genotype (%) | ||||||
|---|---|---|---|---|---|---|
Population and disease | No. | Variant Allele Frequency (%) | Ser/Ser | Ser/Leu | Leu/Leu | P valuea |
Ghana, delivering women | ||||||
P. falciparum positive | 541 | 0.1 | 540 (99.8) | 1 (0.2) | 0 (0) | 0.49 |
P. falciparum negative | 554 | 0 | 554 (100) | 0 (0) | 0 (0) | |
Germany | ||||||
Sepsis patients | 223 | 18.1 | 170 (76.2) | 43 (19.3) | 10 (4.5) | 0.19 |
Controls | 188 | 19.2 | 138 (74.4) | 48 (25.5) | 2 (1.1)b | |
Bangladesh | ||||||
Leprosy patients | 263 | 16.3 | 186 (70.7) | 68 (25.9) | 9 (3.4) | 0.22 |
Controls | 280 | 17.2 | 188 (67.1) | 88 (31.5) | 4 (1.4) | |
Turkey | 0.11 | |||||
Leprosy patients | 60 | 10.8 | 47 (78) | 13 (21) | 0 (0) | |
Controls | 100 | 6.5 | 88 (88) | 11 (11) | 1 (1) | |