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Table 1 Detailed description of sepsis patients

From: Low frequency of the TIRAPS180L polymorphism in Africa, and its potential role in malaria, sepsis, and leprosy

Cohort (n = 223)

Characteristic

aSer/Ser

(n = 170)

aSer/Leu

(n = 43)

aLeu/Leu

(n = 10)

No (%) of patients

Co-existing diseases

   

103 (46.2)

Arterial hypertension

77 (74.8)

22 (21.4)

4 (3.9)

82 (36.8)

Myocardial disease

67 (81.7)

14 (17.0)

1 (1.2)

53 (23.8)

Diabetes

35 (66.0)

14 (26.0)

4 (7.5)

52 (23.3)

Lung pathology

44 (84.6)

6 (11.5)

2 (3.8)

16 (7.2)

Renal pathology

11 (68.8)

4 (25.0)

1 (6.3)

No (%) of patients

Type of surgery

   

76 (34.1)

Upper-GI resection

58 (76.3)

16 (21.1)

2 (2.6)

62 (27.8)

Colorectal resection

46 (74.2)

12 (19.4)

4 (6.5)

50 (22.4)

bOther abdominal

37 (74.0)

10 (20.0)

3 (6.0)

15 (6.7)

Thoracic

11 (73.4)

3 (20.0)

1 (6.7)

20 (9.0)

Limb and others

18 (90.0)

2 (10.0)

- -

No (%) of infections

Type of Infection

   

92 (41.3)

Pneumonia

68 (73.9)

20 (21.7)

4 (4.3)

38 (17.0)

Peritonitis

27 (71.1)

9 (23.7)

2 (5.3)

65 (29.2)

Abscess

52 (80.0)

10 (15.4)

3 (4.6)

4 (1.8)

Urinary tract infections

3 (75.0)

1 (25.0)

- -

24 (10.8)

Other

20 (83.3)

3 (12.5)

1 (4.2)

No (%) of infections c

Microorganisms

   

129 (57.9)

Gram-negative

97 (75.2)

25 (19.4)

7 (5.4)

83 (37.2)

Gram-positive

60 (72.3)

18 (21.7)

5 (6.0)

15 (6.7)

Fungi

13 (86.7)

2 (13.3)

- -

31 (13.9)

Polymicrobial

19 (61.3)

9 (29.0)

3 (9.8)

24 (10.8)

Clinically diagnosed

15 (62.5)

8 (33.3)

1 (4.2)

No (%) of patients

Morbidity and Mortality

   

114 (51.1)

Sepsis without organ dysfunction

90 (78.9)

22 (19.3)

2 (1.8)

109 (48.9)

Severe sepsis and septic shock

80 (73.4)

21 (19.3)

8 (7.3)d

28 (12.6)

Mortality ICU

21 (75.0)

6 (21.4)

1 (3.6)

34 (15.3)

Mortality hospital

26 (76.5)

7 (20.6)

1 (2.9)

  1. aSer/Ser indicates wildtype, Ser/Leu indicates heterozygous and Leu/Leu indicates homozygous individuals. bOther abdominal operations: pancreas-, liver- and multiple visceral organ resection. cNumbers might exceed total number of infections due to multiple or no detections. dIncreased frequency of Leu/Leu in patients with severe sepsis and septic shock compared to patients without organ dysfunction, 7.3 versus 1.8%, P = 0.1. No significant differences were observed by comparing patient characteristics. Abbreviation: ICU: Intensive Care Unit.