Promoter activity assay of the human TIM3 gene promoter constructs. (A) Luciferase activity is presented relative to the PGL3 basic vector after each construct was transfected into YT cells. All values are the mean ± SD of at least five independent experiments. (B) Comparison of the promoter activity and the conserved regions in the human genome. (C) Comparison of the promoter activity between the haplotypes.