Skip to main content

Table 4 GOminer gene ontology analysis of GWAS results, indicating the most over-represented ontological categories.

From: An Open Access Database of Genome-wide Association Results

  Including WTCCC/DGI results (n = 5966 genes) Excluding WTCCC/DGI results (n = 2888 genes)
Gene Ontology category RefSeq genes in Category RefSeq genes observed in GWAS GO category enrichment P-value for enrichment FDR P-value for enrichment
GO:0007155_cell_adhesion 650 309 1.41 4.56E-14 0 1.99E-17
GO:0051056_regulation_of_small_GTPase_mediated_signal_transduction 161 94 1.73 9.73E-11 0 3.76E-06
GO:0051179_localization 2493 975 1.16 1.12E-10 0 2.32E-07
GO:0006810_transport 2128 837 1.17 1.13E-09 0 2.46E-06
GO:0051234_establishment_of_localization 2189 856 1.16 2.64E-09 0 2.92E-06
GO:0006811_ion_transport 682 297 1.29 2.39E-08 0 1.32E-08
GO:0009966_regulation_of_signal_transduction 408 189 1.37 5.37E-08 0 0.00132
GO:0046578_regulation_of_Ras_protein_signal_transduction 122 70 1.70 6.27E-08 0 0.00014
GO:0007156_homophilic_cell_adhesion 134 75 1.66 8.92E-08 0 6.35E-09
GO:0016337_cell-cell_adhesion 245 121 1.46 2.26E-07 0.000091 1.04E-07
GO:0006468_protein_amino_acid_phosphorylation 536 236 1.31 2.43E-07 0.000083 7.42E-07
GO:0043687_post-translational_protein_modification 1171 473 1.20 2.83E-07 0.000154 0.00097
GO:0007265_Ras_protein_signal_transduction 177 92 1.54 3.59E-07 0.000143 0.00013
GO:0006464_protein_modification_process 1399 555 1.18 3.91E-07 0.0002 0.00721
GO:0007242_intracellular_signaling_cascade 1210 486 1.19 4.26E-07 0.000188 0.00040
GO:0006817_phosphate_transport 83 50 1.79 6.31E-07 0.000176 2.10E-05