Table 2 Densest regions of GWAS associations in the human genome based on analysis of 100 kb bins.
From: An Open Access Database of Genome-wide Association Results
Chr | Position | GWAS assoc. in bin | Density rank | LD adj. rank | Min. p value | Gene(s) | Phenotype(s) in decreasing order of occurrence |
|---|---|---|---|---|---|---|---|
10 | 6316580–6390596 | 17 | 92 | 14 | 2.70E-06 | PFKFB3 | LDL cholesterol (4), Total cholesterol (4), Celiac disease (2), RA (2), Waist circumference (2), Bipolar disorder (2), Weight (1) |
13 | 109616103–109677555 | 19 | 67 | 15 | 7.61E-06 | COL4A1 | Weight (11), Type II (2), ALS (2), BMI (1), Height (1), Diastolic blood pressure (1), combined WTCCC cases (1) |
8 | 4621850–4669277 | 27 | 25 | 16 | 1.12E-04 | CSMD1 | HIV-1 viral load set point (25), Crohn's disease (1), combined WTCCC cases (1) |
3 | 21847197–21874359 | 20 | 56 | 17 | 2.00E-05 | intergenic, 3p24.1 | Type II (10), Diastolic blood pressure (4), Bipolar disorder (2), Alzheimer's (2), Parkinson's (1), Crohn's disease (1), combined WTCCC cases (1) |
13 | 23522469–23566520 | 15 | 142 | 18 | 2.62E-04 | SPATA13 | Fat mass (8), Type II (3), Alzheimer's (2), Crohn's (1), RA (1) |
13 | 109706778–109769126 | 9 | 447 | 24 | 2.0E-05 | COL4A1 | HbA1c (3), CAD (2), RA (1), ApoB (1), Crohn's (1), Parkinson's (1), Alzheimer's (1) |
20 | 59002911–59076486 | 17 | 94 | 25 | 2.11E-05 | intergenic, 20q13.33 | CAD (6), Type II (2), combined WTCCC cases (2), HTN (2), RA (1), Crohn's disease (1), Breast cancer (1), Alzheimer's (1), ALS (1) |
2 | 121639597–121685155 | 15 | 143 | 26 | 4.00E-06 | intergenic, 2q14.2 | Alzheimer's (4), Triglyceride/HDL ratio (4), Triglycerides (3), HDL (1), Type I (1), RA (1), Insulinogenic index (1) |
4 | 178511559–178569631 | 10 | 448 | 30 | 6.90E-06 | NEIL3 | ALS (3), Parkinson's (1), Bipolar disorder (1), Type II (1), Type I (1), combined WTCCC cases (1), mFPG (1), heart rate variability (1) |
16 | 76400711–76498035 | 11 | 333 | 32 | 1.10E-04 | KIAA1576 | 2 hr insulin test (5), combined WTCCC cases (2), LV diastolic dimension (1), Fasting insulin (1), HOMA-IR (1), Alzheimer's (1) |
3 | 2801545–2885980 | 11 | 334 | 35 | 2.48E-05 | CNTN4 | Total cholesterol (3), HIV-1 viral load set point (2), combined WTCCC cases (1), RA (1), Waist:height squared (1), 2 hr glucose tolerance test (1), Alzheimer's (1), ALS (1) |
22 | 48109439–48199236 | 9 | 583 | 42 | 3.76E-05 | intergenic, 22q13.32 | Type II (3), CAD (2), HTN (2), LDL (1), Small vessel stroke (1) |
7 | 77505244–77596871 | 17 | 95 | 44 | 1.38E-04 | MAGI2 | BMI (5), Waist circumference (5), Waist:height squared (5), HTN (1), ALS (1) |
16 | 6603645–6620427 | 15 | 145 | 45 | 2.31E-05 | A2BP1 | HOMA-IR (6), Fasting insulin (4), 2 hr insulin test (3), RA (1), Nicotine dependence (1) |
8 | 134608378–134674046 | 14 | 177 | 46 | 5.66E-05 | ST3GAL1 | Type II (6), Alzheimer's (6), Crohn's disease (2) |
11 | 113445679–113499715 | 13 | 221 | 47 | 1.25E-05 | ZBTB16 | Waist circumference (4), HDL (3), BMI (2), Weight (2), Type II (1), LDL (1) |
8 | 4200701–4270026 | 10 | 450 | 51 | 2.79E-04 | CSMD1 | HIV-1 (4), HTN (1), Systolic blood pressure (1), Type I (1), FPG (1), Colorectal cancer (1), Alzheimer's (1) |
20 | 54803001–54891697 | 8 | 761 | 52 | 2.65E-04 | intergenic, 20q13.31 | ApoB (2), CAD (1), HTN (1), Fasting glucose (1), 2 hr glucose (1), Alzheimer's (1), Triglyceride/HDL ratio (1) |
13 | 109813629–109898019 | 15 | 146 | 53 | 1.89E-05 | COL4A2 | Type II (10), CAD (2), HTN (1), ALS (1), Alzheimer's (1) |
16 | 82802796–82891261 | 8 | 762 | 54 | 1.60E-05 | KCNG4, WFDC1 | HIV-1 (2), Type II (1), Crohn's disease (1), Fat mass (1), Insulinogenic index (1), ALS (1), combined WTCCC cases (1) |
6 | 164313234–164367157 | 22 | 44 | 135 | 3.84E-05 | intergenic, 6q26 | Insulinogenic index (14), LDL (3), HOMA-IR (2), Alzheimer's (1), Parkinson's (1), RA (1) |
13 | 63720215–63799016 | 24 | 33 | 148 | 7.46E-05 | intergenic, 13q21.31 | HDL cholesterol (8), Waist circumference (7), Weight (5), CAD (2), BMI (1), Gallstone disease (1) |
3 | 162876798–162898990 | 24 | 34 | 229 | 2.41E-05 | intergenic, 3q26.1 | BMI (7), Waist circumference (6), Waist:height (6), Weight (2), Early onset Type II (1), Hypertension (1), Crohn's disease (1) |
12 | 58400177–58492903 | 35 | 18 | 267 | 1.12E-05 | SLC16A7 | Crohn's disease (21), HDL (14) |
21 | 40500455–40546492 | 22 | 46 | 326 | 9.05E-05 | DSCAM | Height (11), Weight (7), Waist circumference (4) |
12 | 111841825–111894699 | 22 | 47 | 440 | 5.92E-05 | OAS1/2/3, RPH3A | Crohn's disease (18), Type I (4) |
7 | 86415282–86498669 | 23 | 40 | 1434 | 1.60E-04 | KIAA1324L | Type II (20), Triglyceride/HDL ratio (2), CAD (1) |
4 | 35101778–35198927 | 23 | 41 | 1569 | 7.72E-05 | intergenic, 4p15.1 | Nicotine dependence (21), Type I (1), Hypertension (1) |