The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts

Table 3 Association of INSIG2 rs7566605 CC genotype and anthropometric measures stratified by cohort and race

	n	Weight (± SD) GG/CG	Weight (± SD) CC	p*	p¹	Waist (± SD) GG/CG	Waist (± SD) CC	p*	p¹	Waist-to-Hip Ratio (± SD) GG/CG	Waist-to-Hip Ratio (± SD) CC	p*	p¹
ARIC Afr.-Am.	3,869	83.36 (17.47)	85.31 (17.46)	0.12		99.02 (15.20)	100.79 (14.37)	0.06		0.918 (0.076)	0.932 (0.072)	0.01
CARDIA Afr.-Am.	1,885	72.96 (18.02)	73.48 (16.68)	0.73		78.48 (12.40)	79.40 (11.35)	0.41		0.774 (0.067)	0.778 (0.062)	0.36
GENOA Afr.-Am.	1,731	88.04 (18.70)	85.33 (17.01)	0.10		103.11 (16.50)	101.49 (17.09)	0.44		0.911 (0.076)	0.916 (0.083)	0.61
ARIC White	10,690	77.13 (16.34)	76.71 (16.14)	0.32		96.31 (13.42)	95.68 (13.34)	0.08		0.929 (0.079)	0.925 (0.079)	0.04
CARDIA White	1,997	69.91 (14.45)	70.24 (16.72)	0.60		77.18 (10.56)	77.59 (12.28)	0.43		0.779 (0.074)	0.782 (0.074)	0.17
GENOA White	1,418	86.85 (19.96)	84.64 (17.19)	0.45		100.35 (15.80)	98.56 (13.30)	0.37		0.914 (0.092)	0.908 (0.088)	0.88
GENOA Hispanic	1,613	82.05 (17.75)	80.01 (15.54)	0.11		106.77 (14.47)	106.03 (12.33)	0.55		0.975 (0.088)	0.984 (0.067)	0.17
Combined Studies	23,203	79.04 (17.8)	77.83 (17.04)		0.32	95.21 (16.24)	94.28 (15.49)		0.38	0.902 (0.098)	0.903 (0.096)		0.74

Afr.-Am., African-American; n, number; SD, standard deviation; *adjusted for age and sex; p, p value for analysis of mean differences in anthropometric measures among INSIG2 rs7566605 genotypes using general linear model; p¹, p-value for
analysis of mean differences in anthropometric measures among INSIG2 rs7566605 genotypes using a general linear model and adjusting for age, gender, race, and study after combining participants from all three cohorts

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