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Table 3 Association of INSIG2 rs7566605 CC genotype and anthropometric measures stratified by cohort and race

From: The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts

  n Weight
(± SD)
GG/CG
Weight
(± SD)
CC
p* p1 Waist
(± SD)
GG/CG
Waist
(± SD)
CC
p* p1 Waist-to-Hip Ratio
(± SD)
GG/CG
Waist-to-Hip Ratio
(± SD)
CC
p* p1
ARIC
Afr.-Am.
3,869 83.36 (17.47) 85.31 (17.46) 0.12   99.02
(15.20)
100.79
(14.37)
0.06   0.918
(0.076)
0.932
(0.072)
0.01  
CARDIA
Afr.-Am.
1,885 72.96 (18.02) 73.48 (16.68) 0.73   78.48
(12.40)
79.40
(11.35)
0.41   0.774
(0.067)
0.778
(0.062)
0.36  
GENOA
Afr.-Am.
1,731 88.04
(18.70)
85.33
(17.01)
0.10   103.11
(16.50)
101.49
(17.09)
0.44   0.911
(0.076)
0.916
(0.083)
0.61  
ARIC
White
10,690 77.13 (16.34) 76.71 (16.14) 0.32   96.31
(13.42)
95.68
(13.34)
0.08   0.929
(0.079)
0.925
(0.079)
0.04  
CARDIA
White
1,997 69.91 (14.45) 70.24 (16.72) 0.60   77.18
(10.56)
77.59
(12.28)
0.43   0.779
(0.074)
0.782
(0.074)
0.17  
GENOA
White
1,418 86.85
(19.96)
84.64
(17.19)
0.45   100.35
(15.80)
98.56
(13.30)
0.37   0.914
(0.092)
0.908
(0.088)
0.88  
GENOA
Hispanic
1,613 82.05
(17.75)
80.01
(15.54)
0.11   106.77
(14.47)
106.03
(12.33)
0.55   0.975
(0.088)
0.984
(0.067)
0.17  
Combined
Studies
23,203 79.04
(17.8)
77.83
(17.04)
  0.32 95.21
(16.24)
94.28
(15.49)
  0.38 0.902
(0.098)
0.903
(0.096)
  0.74
  1. Afr.-Am., African-American; n, number; SD, standard deviation; *adjusted for age and sex; p, p value for analysis of mean differences in anthropometric measures among INSIG2 rs7566605 genotypes using general linear model; p1, p-value for
  2. analysis of mean differences in anthropometric measures among INSIG2 rs7566605 genotypes using a general linear model and adjusting for age, gender, race, and study after combining participants from all three cohorts