Skip to main content

Table 1 INSIG2 allele and genotype frequencies in case and comparison groups stratified by race and cohort

From: The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts

  n HW
(p1)
q^
(%)
Obese
(n)
(%) GC
n
(%)
CG
n
(%)
CC
n
(%)
Non-
Obese
(n)
(%) GC
n
(%)
CG
n
(%)
CC
n
(%)
(p2)
ARIC
Afr.-Am.
3,870 0.80 24.8 1,570 40.6 910
(57.9)
563
(35.9)
97
(6.2)
2,300 59.4 1,281
(55.7)
875
(38.0)
144
(6.3)
0.36
CARDIA
Afr.-Am.
1,887 0.14 25.6 321 17.0 184
(57.3)
113
(35.2)
24
(7.5)
1,566 83.0 873
(55.7)
581
(37.1)
112
(7.2)
0.81
GENOA
Afr.-Am.
1,731 0.15 25.8 859 49.6 464
(54.0)
350
(40.8)
45
(5.2)
872 50.4 477
(54.7)
356
(38.5)
59
(6.8)
0.32
ARIC
White
10,696 0.61 33.2 2,430 22.7 1,099
(45.2)
1,070
(44.0)
261
(10.8)
8,266 77.3 3,689
(44.6)
3,649
(44.2)
928
(11.2)
0.76
CARDIA
White
2,001 0.34 33.8 142 4.4 59
(41.5)
65
(45.8)
18
(12.7)
1,859 95.6 828
(44.6)
811
(43.6)
220
(11.8)
0.78
GENOA
White
1,421 0.06 31.6 647 45.5 302
(46.7)
290
(44.8)
55
(8.5)
774 54.5 348
(44.9)
355
(45.9)
71
(9.2)
0.78
Ottawa
Cohort 1
White
754 0.57 33.5 380 50.4 176
(46.3)
164
(43.2)
40
(10.5)
374 49.6 161
(43.1)
165
(44.1)
48
(12.8)
0.51
Ottawa
Cohort 2
White
748 0.82 32.2 371 49.6 175
(47.2)
155
(41.8)
41
(11.0)
377 50.4 168
(44.6)
174
(46.1)
35
(9.3)
0.44
GENOA
Hispanic
1,614 0.43 26.6 793 49.1 421
(53.1)
313
(39.5)
59
(7.4)
821 50.9 456
(55.5)
304
(37.0)
61
(7.5)
0.58
  1. Afr.-Am., African-American; n, number; HW, Hardy-Weinberg equilibrium; q^, frequency of the INSIG2 rs7566605 C allele; p1, p-value for chi-squared goodness-of-fit test for Hardy-Weinberg equilibrium; p2, p-value Pearson chi-squared